2012年安徽省六安市中医院临床分离细菌谱及其耐药监测

Surveillance of drug resistance of pathogens isolated from Lu'an Hospital of Traditional Chinese Medicine of Anhui province in 2012

目的:了解六安市中医院2012年临床分离细菌及其对常用抗菌药物的耐药情况。方法:采用纸片扩散法(K-B法)进行抗菌药物药敏试验。结果:临床分离的769例细菌中,革兰阴性菌占69.8%,革兰阳性菌占30.2%。革兰阳性菌中金黄色葡萄球菌和凝固酶阴性葡萄球菌及肠球菌分别占45.69%、42.24%、8.62%,其他阳性菌占3.45%。检出1例肠球菌对糖肽类抗生素万古霉素耐药,耐药率为5.0%(1/20)。产超广谱β-内酰胺酶的肺炎克雷伯菌、大肠埃希菌的检出率分别为38.9%(37/95)和48.6%(52/107)。鲍曼不动杆菌184株,对碳青霉烯类抗菌药物的耐药率>40.0%。嗜麦芽窄食单胞菌27株,对左氧氟沙星、替卡西林/克拉维酸的耐药率较低。未发现范耐药菌株。结论:2012年六安市中医院临床分离菌以革兰阴性菌为主,其中鲍曼不动杆菌对碳青霉烯类抗菌药物耐药率较高,肠杆菌对碳青霉烯类敏感性高。

Objective：To investigate the bacteria strain isolated from Lu＇ an Hospital of Traditional Chinese Medicine and its drug resistance in 2012. Methods：The antimicrobic drug sensitive test was determined by Kirby-Bauer method. Results：During 769 isolated bacteria strains,69.8% of gram-negative bacteria and 30.2% of gram-positive bacteria（ including 45.69% of Staphylococcus aureus, 42.24% of Coagulase negative Staphylococcus, 8. 62% of Enterococus and 3.45% of other positive bacteria） were found. One Enterococcus bacterium strain resistanting to Sugar peptide antibiotic vancomycin was detected, its drug resistance rate was 5.0% （1/20）. The detection rate of Pneumonia klebsiella and Escherichia coli were 38.9% （37/95） and 48.6% （52/107）, respectively. The drug resistance rate of 184 Baumanii strains resistanting to carbapenems was more than 40. 0%. The drug resistance rates of 27 Stenotrophomonas maltophilia strains resistanting to levofloxacin and Ticarcitlin/clavulanic acid were low. Conclusions： Gramnegative bacteria is the main bacteria in Lu＇ an Hospital of Traditional Chinese Medicine in 2012. The Acinetobacter spp was highly resistance to carbapenem,Enterobacteriaceae was highly sensitive to carbapenem, and pan-drug resistant strain was not found.