期刊文献+

雷贝拉唑钠肠溶片制备及其溶出度测定 被引量:3

下载PDF
导出
摘要 目的制备雷贝拉唑钠肠溶片。方法采用处方筛选对其片芯各组分组成,隔离衣、肠溶衣处方及包衣增重进行了考察,并采用溶出度测定确定处方。结果所优选的处方具有肠溶功能。结论片芯中羟丙基纤维素、低取代纤维素是其主要影响因素,肠溶衣包衣增重为12%或18%时药物具有较好的抗酸力,可达到肠道给药的目的,但随着肠溶衣包衣增重的增加药物释放有减缓的趋势。
作者 尹辉
出处 《安徽医药》 CAS 2014年第1期45-47,共3页 Anhui Medical and Pharmaceutical Journal
  • 相关文献

参考文献8

二级参考文献42

共引文献49

同被引文献40

  • 1常颖,郑启泰,吕扬.X射线衍射分析技术在药物研究中的应用[J].物理,2007,36(6):452-459. 被引量:21
  • 2Beral A,Mukherjee A.Approved proton pump inhibitor:a comparative study[J].Inter J Pharmac Res Develop,2013,4(12):37.
  • 3Pharmacopoeia Commission of India.Indian pharmacopoeia[S].2010:2 037-2 038.
  • 4Surekha Y,Venugopalaiah P,Prakash KG,et al.Design and characterization of enteric coated delayed release pellets of rabeprazole sodium[J].Research Journal of Pharmacy and Technology,2013,6(12):422.
  • 5Khalil AA, Kabapy NF, Deraz SF, et al. Heat shock proteins in on- cology: Diagnostic biomarkers or therapeutic targets? [ J]. Bio-chim Biophys Acta,2011,16(2) : 89 -104.
  • 6Schulze U, Hampel U, Sel S, et al. Fresh and eryopreserved amni- otic membrane secrete the trefoil factor family peptide 3 that is well known to promote wound healing [ J ]. Histochem Cell Biol, 2012, 138(2) :161 - 166.
  • 7Guth PH, Aures D, Paulsen G. Topical aspirin plus HC1 gastric le- sions in the raf. Cytoprotective effect of prostaglandin, cimetidine and probanthine [ J ]. Gastroenterology, 1979,76 ( 1 ) : 88 - 93.
  • 8Alison MR, Chinery R, Poulsom leads to sequential expression of R, et al. Experimental ulceration spasmolytic polypeptide, intesti- nal polypeptide, intestinal trefoil factor and transforming growth factor alpha mRNA in rat stomach [ J ]. J Pathol, 1995, 175 (4) : 405.
  • 9Hoffmann W. TFF( trefoil factor family) peptide - triggered signals promoting mucosal restitution [ J ]. Cellular and Molecular Life Sci- ences,2005,62(24) :2932 -2938.
  • 10Suemasu S,Tanaka K,Namba T,et al. A role for HSP70 in protec- ting against indomethacin - induced gastric lesions [ J ]. J Biol Chem, 2009,284(29) : 19705 - 19715.

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部