77例骨肉瘤患者预后的多因素分析

Multivariate analysis on prognostic factors among 77 patients with osteosarcoma

目的:探讨影响骨肉瘤患者预后的相关因素。方法:回顾性分析2000年1月至2011年10月,77例资料完整骨肉瘤患者的临床资料,并根据是否接收化疗药物治疗且坚持4个周期以上分为规律化疗组及非规律化疗组。结果:规律化疗组患者的比例为54.55%(42/77),非规律化疗组的比例为45.45%(35/77)。所有患者生存时间为9-62个月,5年总体生存率为44.16%(34/77),平均生存时间36.71±14.80个月,中位生存时间为31个月。规律化疗组患者5年生存率(50.00%,21/42)显著高于非规律化疗组(37.14%,13/35)(Log Rank:χ2=8.27,P=0.004);COX多因素分析发现:Enneking分期、手术方式及规律化疗是影响骨肉瘤患者5年生存率的独立因素。结论:Enneking分期、手术方式及规律化疗是影响骨肉瘤患者预后的独立因素。

Objective：To investigate the prognostic factors that influence survival in patients with osteosarcma. Methods：The clinical data of 77 patients with osteosarcoma,among which the combined therapy （resection of tumor with chemotherapy） and uncombined therapy group,based on whether receiving chemotherapy drug therapy and adhering to the four cycle or above or not,between January 2000 and October 2011 were retrospectively reviewed. Results： The proportion of patients of combined therapy group was 54.55% （42/77） , and the proportion in uncombined therapy group was 45.45% （35/77）. The survival time ranged from 9 to 62 months with a median survival of 31 months,with overall 5 year overall smwival rate 44.16% （34/77）. The survival rate（50.00% ,21/42） in combined therapy group,was significantly higher than that in the tmeombined therapy group（37.14% , 13/35） ,P 0. 004. Multivariate analysis by COX regression model suggested Enneking stage,surgical method and combined therapy were the independent prognostic factors. Conclusion： Enneking stage, surgical method and combined therapy were the independent prognostic factors that influenee survival in patients with osteosarema.