益母草肌内注射与米索前列醇含服预防阴道分娩产后出血的效果观察

Clinical observation of Yimucao Injection combined misoprostol for preventing postpartum hemorrhage after vaginal delivery

目的探讨益母草肌内注射与米索前列醇含服在阴道分娩中预防产后出血的效果。方法将正常的单胎头位足月妊娠阴道分娩者240例随机分为益母草组、米索前列醇组和益母草+米索前列醇组,每组80例。米索前列醇组于胎儿前肩娩出后立即含服米索前列醇片,益母草组在胎儿娩出后宫壁注射益母草注射液,12h后肌内注射,益母草+米索前列醇组在益母草组基础上于胎儿前肩娩出后立即含服米索前列醇片。观察产后2h及24h出血量及第三产程时间。结果益母草+米索前列醇组产后2h及产后24h出血量均明显少于米索前列醇组和益母草组,第三产程短于米索前列醇组和益母草组,差异均有统计学意义(P<0.05)。结论米索前列醇、益母草均可用于产后出血的预防,给药方便,益母草联合米索前列醇对预防和减少产后出血有良好的作用,便于推广应用。

Objective To investigate the effect of Yimucao Injection combined misoprostol for preventing postpartum hemorrhage after vaginal delivery. Methods. A total of 240 women were randomly divided into 3 groups ： motherwort injection group, misoprostol group and motherwort injection ＋ misoprostol group, each of 80 cases. The motherwort injection group ： moth- erwort injection 20mg into the uterine muscle after the delivery of fetus;the misoprostol group：put 600μg of misoprostol under the tongue as soon as the fetal anterior shoulder was delivered;while for the motherwort injection ＋ misoprostol group, mother- wort injection 20mg into the uterine muscle after the delivery of fetus and put 600μg of misoprostol under the tongue as soon as the fetal anterior shoulder was delivered. The amount of bleeding within 2 and 24 h after the delivery and the length of the third stage of labor were compared between the 3 groups. Results The amount of bleeding within 2 and 24 h after the delivery in the motherwort injection ＋ misoprostol group were significantly less than those in the other group, the length of the third stage of labor in the motherwort injection ＋ misoprostol group was shorter than that of the other group, and the differences were statisti- cally significant （P 〈 0.05）. Conclusion Misoprostol plus motherwort injection is more effective and safe in reduction and prevention of atonic postpartum hemorrhage.