摘要
目的研究盐酸兰地洛尔粉针剂与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液以及葡萄糖氯化钠注射液配伍后的稳定性。方法采用高效液相色谱法(HPLC)测定注射用盐酸兰地洛尔与4种常用输液于室温(25℃)配伍4h内的含量,并测定不溶性微粒及pH值变化。结果注射用盐酸兰地洛尔与上述4种输液配伍放置4h后,pH值、不溶性微粒、含量均无明显改变。结论注射用盐酸兰地洛尔在上述4种输液中4h内稳定性良好。
Objective To study the compatible stability of landiolol hydrochloride For Injection in 0.9% sodium chloride injection,5% glucose injection, 10% glucose injection and glucose and sodium chloride injection. Methods The content of landiolol hydrochloride during 4h was determined by high-pressure liquid chromatography（HPLC） when mixed with 4 kinds of infusions at room temperature（25℃ ）. The particulate matter and pH value was measured. Results After landiolol hydrochloride for injection was mixed with each of the four kinds Of infusions, the contents , the number of particles and pH val- ue had no obvious change in 4h. Conclusion Landiolol hydrochloride for injection has good compatible stability in the 4 kinds of infusions.
出处
《临床合理用药杂志》
2014年第2期29-30,共2页
Chinese Journal of Clinical Rational Drug Use
