老年人梅毒螺旋体抗体的检测分析

Analysis of treponema pallidum antibody in elderly individuals

目的探讨梅毒螺旋体特异性抗体对诊断老年人梅毒感染的价值。方法对本院7 833例住院病人梅毒螺旋体抗体检测结果结合临床资料进行回顾性分析。结果 60岁以上老年人群梅毒抗体阳性率为4.96%,60岁以下人群阳性率为3.44%,差异有统计学意义(P<0.01),但经临床确诊后前者梅毒螺旋体抗体假阳性率(1.56%),明显高于后者(0.21%),差异有统计学意义(P<0.01)。结论 60岁以上老年人的梅毒螺旋体抗体试验存在着较青壮年高的假阳性率。老年人梅毒感染更应结合临床表现及病史慎重作出诊断。

Objective To explore the value of treponema pallidum antibody in the diagnosis of syphilis in the elderly. Methods The outcomes of treponema pallidum antibody test of 7 833 hospitalized patients were retrospectively analyzed, in combination with clinical data. Results The positive rate of treponema pallidum antibody in the elderly individuals over 60 years of age was 4.96% , while that in those under 60 years of age was 3.44%. The difference was statistically significant （ P 〈 0.01 ）. After clini- cally confirmed diagnosis, false positive rate was higher in the former group （ 1.56% ） than in the latter group （0.21%）. The difference was also statistically significant （P 〈 0.01 ）. Conclusion False positive rate of treponema pallidum antibody test in the elderly individuals over 60 years of age is relatively high. In combination with clinical manifestation and medical history, doctors should be more careful when a diagnosis of syphilis is to be made.