一个描述GAV-9肽在不同pH值环境下界面水层中自组装行为的模型

A Model Describing Self-assembly Behaviors of GAV-9 Peptide in Water Nanofilm Under Different pH Atmospheres

pH值在很多生物过程中起到了重要作用,不仅在溶液中,在界面环境中也是如此.研究了GAV-9肽在酸性和碱性氛围下界面水层中的自组装行为.发现GAV-9肽在酸性氛围下自组装得到有序的纳米细丝,但在碱性氛围下自组装得到无序的纳米片层.此外,体相实验显示,GAV-9肽在中性和碱性溶液中自组装得到有序的纳米细丝,但在酸性溶液中未在云母表面吸附.基于此结论,提出以下模型:在中性和酸性氛围下,GAV-9肽是在固液界面上进行自组装的;在碱性氛围下,GAV-9肽是在气液界面上进行自组装的.

pH plays an important role in many biological processes,not only in bulk solutions, but also in confined environments. In this paper,we studied the self-assembly behaviors of GAV-9 peptide in water nanofilm under different pH atmospheres. It was found that GAV-9 peptide self-assembled into ordered nanofilaments under an acidic atmosphere but into randomly oriented nanosheets under an alkaline atmos- phere. In addition,bulk experiments showed that GAV-9 assembled into ordered nanofilaments on mica in neutral and alkaline solutions,while it did not adsorb on the substrate in an acidic solution. Based on these results,we proposed a model that GAV-9 self-assembled at the water/solid interface under neutral and acidic atmospheres,while the process was conducted at the vapor/water interface under an alkaline atmos- phere.