芳香化酶P450Arom在卵巢浆液性腺癌的表达及临床意义

Expression of P450Arom in Ovarian Serous Adenocarcinoma and Its Clinical Significance

[目的]探讨芳香化酶P450Arom与卵巢浆液性腺癌的相关性及对患者预后的影响。[方法]采用免疫组织化学方法检测57例卵巢浆液性腺癌标本中P450Arom的表达,并分析其与患者临床病理特征及预后的相关性。[结果]57例卵巢浆液性腺癌组织中P450Arom阳性率为61.40%,不同分期以及不同分级的患者之间表达有差异(P=0.016;P=0.000),肿瘤分期越高、分化越差,P450Arom表达阳性率越高。P450Arom阳性表达患者预后差,P450Arom表达状况与患者年龄无关(P>0.05)。Cox多因素回归分析显示卵巢浆液性腺癌中P450Arom表达可增加患者死亡风险。[结论]卵巢浆液性腺癌组织中存在P450Arom表达,且与患者的预后差可能相关,可为芳香化酶抑制剂在卵巢浆液性腺癌上的应用提供一定参考依据。

[ Purpose ] To investigate the correlation between P450Arom and ovarian serous adenocarci- noma,and the impact of expression of P450Arom on prognosis of the patients. [Methods] Expression of P450Arom was detected immunohistochemically in 57 samples of ovarian serous adenocarcinoma,and correlation between expression of P450Arom and clinicopathological features or prognosis was analyzed. [Results] In the 57 cases,the positive rate of P450Arom was 61.40%.There was significant difference of expression of P450Arom in patients with various stages （P=0.016） or in patients with various grades （-P=-0.O06）. The higher the stage,or the poor the differentiation,the higher the positive expres- sion of P450Arom was found . Poor prognosis was found in P450Arom positive expression patients. There was no relationship between P450Arom expression and age （P〉0.05）. Multivariate survival analysis showed that P450Arom positive expression increased the risk of death. [Conclusion] Positive expres- sion of P450Arom in the ovarian serous carcinoma might be associated with poor prognosis,which might provide evidence for the application of P450 enzyme inhibitors in patients with ovarian serous adenocarcinoma.