慢性阻塞性肺疾病急性加重期降钙素原与炎症因子的相关性分析

Correlation between procalcitonin and inflammatory cytokines in acute exacerbation of COPD

目的：研究慢性阻塞性肺疾病（COPD）急性加重期患者血清降钙素原（PCT）与炎症因子的相关性。方法：回顾性分析我院2011年1月-2013年1月收治的50例慢性阻塞性肺疾病急性加重期患者的临床资料，选择慢性阻塞性肺疾病急性加重期患者为观察组，以同期体检的正常健康人为对照组，比较两组研究对象血常规、PCT和炎症因子的差异，采用Spearman秩相关分析PCT与炎症因子的相关性。结果：观察组患者白细胞（WBC）、红细胞（RBC）和中性粒细胞（NEU）显著高于对照组（P均〈0．05），血小板（PLT）和淋巴细胞（LYM）无明显差异（P〉0．05）。观察组患者的白细胞介素（IL）-18、IL-6、IL-8以及高敏C-反应蛋白（hs—CRP）、肿瘤坏死因子-α（TNF-α）均高于对照组，IL-10明显低于对照组，差异均有统计学意义（P〈0．05）。血清PCT和IL-1β、IL-6、IL-8以及hs—CRP、TNF-α呈现正相关的关系，而与IL-10呈负相关（P均〈0．05）。结论：慢性阻塞性肺疾病急性加重期患者血清PCT显著高于正常健康人，其水平与IL-1β、IL-6和IL-8以及hs—CRP、TNF-α呈正相关，和IL-10呈负相关。

Objective. To study the correlation between procalcitonin （PCT） and inflammatory cy- tokines in acute exacerbation of COPD. Methods： The patients with acute exacerbation of COPD were cho- sen as observation group, while the healthy people were as control group. The blood routine, procalcitonin and inflammatory cytokines were compared. The correlation between procalcitonin and inflammatory cyto- kines was analyzed. Results： The PCT, hs-CRP, TNF-α,IL-1β, IL-6 and IL-8 in observation group were significantly higher than in control group （P〈0.05）, while the IL-10 was lower （P〈0.05）. PCT was positively correlated with hs-CRP, TNF-α, IL-ll3, IL-6 and IL-8, while negatively with IL-10. Conclusions. PCT in acute exacerbation of COPD is higher than that in healthy people. PCT is positively correla- ted with hs-CRP, TNF-α, IL-1β, IL-6 and IL-8, while negatively with IL-10.