老年骨性关节炎患者炎症因子与疾病活动的关系

Relationship between senile osteoarthritis and inflammatory factors in patients with active disease

目的:研究老年骨性关节炎患者炎症因子与疾病活动的关系。方法:分析在我院接受住院治疗的老年骨性关节炎(osteoarthritis,OA)患者的临床资料,分为活动组和缓解组,观察分析两组血液和关节液的炎症指标。结果:活动组的VAS疼痛评分,血液炎症指标C-反应蛋白(CRP)、血沉(ESR)和肿瘤坏死因子-α(TNF-α),关节液炎症因子白介素-1β(IL-1β)和基质金属蛋白酶-3(MMP-3)指标均要高于缓解组,差异具有统计学意义(P<0.05)。VAS疼痛评分与IL-1β呈正相关(r=1.526,P=0.011)。结论:老年OA患者炎症因子与疾病活动具有相关性,在一定程度上能够通过患者炎症水平反应患者的疾病严重程度。

Objective： To study the relationship between inflammatory factors and disease activity in elderly patients with osteoarthritis inflammation. Methods： Clinical data of OA patients were analyzed, these patients were divided into active group and remission group, and inflammatory factors in both blood and synovial fluid were analyzed and compared between the two groups. Results： In the active group, VAS pain scores, blood inflammatory markers CRP, ESR and TNF-α, IL-1β, synovial fluid inflammatory fac- tor TNF-α and MMP3 index were higher than those in remission group （all P 〈0. 05）. The VAS pain score was positively correlated with IL-1β level （r= 1. 526, P=0. 011）. Conclusion： In senile OA patients, inflammatory factors are positively correlated with disease activity, thus they can reflect severity of the disease.