首发抑郁症患者对情绪词注意偏向相关研究

Investigation of attentional bias to emotional-related words in first.episode depressive patients

目的探讨首发型抑郁症患者注意偏向特点。方法选取34例未经治疗的首发型抑郁症患者以及与其人口学资料相匹配的40例健康对照组（HC）作为研究对象，采用中文情绪词stroop实验进行注意偏向的测试。结果患者组在负性词、中性词、正性词的反应时[分别为（1185．71±410．60）ms，（1127．92±344．89）ms，（1166．17±395．72）ms]，高于HC组[分别为（754．68±215．36）ms，（755．37±213．49）ms，（761．70±194．66）ms]，差异有统计学意义（t=5．775，P〈O．01；t=5．675，P〈0．01；t=5．708，P〈0．01）；方差分析显示患者组在负性词、中性词、正性词的错误数[（3．41±2．11）次，（2．24±1．65）次，（2．97±1．17）次]方面差异有统计学意义（F=4．197，P=0．018），LSD（Leastsignificantdifference）进一步两两比较发现，负性词与中性词差异有统计学意义（P〈0．01）。结论抑郁症患者在治疗前对负性词具有显著的注意偏向，对负性相关刺激的注意偏向可能是抑郁症患者认知特质之一。

Objective To explore the attentional bias in first-episode depressive patients and the correla- tions between the attentional bias. Methods In the beginning of the treatment, a total of 34 first-episode depres- sive patients in treatment-naive and demography matched 40 healthy controls completed the Chinese Emotional Stroop Task that assessed the attentional bias. Results The comparison between depressive patients and healthy controls on the reaction time of negative, neutral and positive-related words were significant （ （ 1185.71± 410.60 ） ms/（754.68±215.36） ms, t= 5.775, P〈0.01 ; （1127.92±344.89） ms/（755.37±213.49） ms, t= 5.675, P〈0.01 ; （1166.17±395.72） ms/（ 761.70± 194.66） ms, t= 5.708, P〈0.01 respectively） .Through analysis of variance, the difference of error numbers among the neutral, negative and positive-related words （ （ 3.41 ± 2.11 ） times, （ 2.24 ± 1.65 ） times, （ 2.97±1.17） times） in the depressive patients were significant （ F= 4.197, P= 0.018 ） .The difference of error numbers between negative-related words and nentral-related words were significant through analysis of least significant difference（P〈0.01）.Conclusion The results suggest that depressive patients before treatment have at- tentional bias in negative-related word.Attentional bias in negative-related stimuli may be one of the characteristics of cognitive function in first-episode depressive patients.