念珠菌腹膜炎:防患于未然

Candida Peritonitis:Nip in the Bud

念珠菌腹膜炎多见于继发性腹膜炎、第三型腹膜炎,早期诊断较为困难,易漏诊,病死率高。念珠菌黏膜定植和宿主天然屏障破坏易使患者感染念珠菌,而外科手术是导致念珠菌腹膜炎的最主要危险因素之一。术中获取腹水标本念珠菌培养阳性或腹腔组织样本病理学检查确诊仍被认为是诊断的"金标准"。抗原、抗体相关检测方法可以弥补常规诊断方法的缺点与不足。药物干预治疗的时机与方法一直是临床关注的焦点。本文对念珠菌腹膜炎的流行病学特点、风险因素以及诊治相关问题进行了总结,以期能够加深临床医师对念珠菌腹膜炎的认识与理解。

Candida peritonitis is commonly seen in secondary peritonitis and tertiary peritonitis, early diagnosis is difficult with high mortality. Candidal mucosal colonization and host natural barrier damage facilitate to candida infection, and surgical operation is one of the leading risk factors of Candida peritonitis. To date, histopathological confirmation of Candida spp. In abdominal tissue or growth of Candida spp from peritoneal fluids sampled intraoperatively is usually considered a ＂gold standard＂ of diagnosis. Detection of antibody and antigen can offset the shortcomings of conventional diagnosis method. The timing and method of drug intervention is always the focus of clinical treatment. This review summarized the epidemiological characteristics, risk factors and treatment of Candida peritonitis to deepen the cognition and understanding of Candida peritonitis.