阴道上皮内瘤变诊治进展

Progress on the diagnosis and treatment of vaginal intraepithelial neoplasia

阴道上皮内瘤变(Vaginal intraepithelial neoplasia,VaIN)是一种少见的阴道癌前病变。其发生的高危因素包括高龄、高危型人乳头瘤病毒感染、宫颈上皮内瘤变或宫颈癌病史及既往放射治疗史。VaIN多无明显症状,诊断方法为细胞学筛查、阴道镜指导下活检及高危型人乳头瘤病毒检测。VaIN的治疗方法包括局部药物治疗、CO2激光汽化治疗、超声抽吸治疗、手术切除和腔内放射治疗。由于VaIN具有易复发的特征,需要进行长期的随访。

Vaginal intraepithelial neoplasia（VaIN） is an infrequent pre-invasive lesion of vagina. High-risk factors for the development of vaginal intraepithelial neoplasia are advanced age, high-risk human papillomavirus infection, history of cervical intraepithelial neoplasia or cervical cancer,history of radiation therapy. VaIN is usually asymptomatic and the diagnostic methods are cytologic screening, colposcopy directed biopsy and high-risk human papillomavirus testing. Therapeutic modalities include topical drug application, CO2 laser vaporization ,ultrasonic surgical aspiration, surgical excision and intracavitary brachytherapy. A long-term follow- up is required due to the recurrent character of VAIN.