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Connexin43及其相关蛋白相互作用对细胞通信的影响 被引量：1

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摘要 间隙连接蛋白43(Cx43)是构成细胞间隙通信(GJIC)的主要结构蛋白,Cx43的相关蛋白通过影响Cx43在细胞内的运输、定位及结构,促使GJIC功能发生变化,进而对细胞的代谢功能及细胞病理状态产生不同作用。本文就细胞骨架蛋白、非受体酪氨酸蛋白激酶Src、细胞支架蛋白(ZO-1)及其泛素蛋白成员CIP75等相关蛋白与Cx43相互作用,及其对细胞间连接通信的影响作一综述。
作者 陈春桂 林珏龙
机构地区 汕头大学医学院细胞分析实验室
出处 《汕头大学医学院学报》 2013年第4期242-244,共3页 Journal of Shantou University Medical College
关键词 细胞间隙连接通信 间隙连接蛋白43 骨架蛋白 细胞支架蛋白-1 Src 泛素蛋白CIP75
分类号 Q291 [生物学—细胞生物学]
  • 相关文献

参考文献23

  • 1JONGSMA H J, WILDERS R. Gap junctions in cardio- vascular disease [J] . Circulation Research, 2000, 86(12): 1193-1197.
  • 2GIEPMANS B N G, VERLAAN I, HENGEVELD T, et al. Gap junction protein counexin-43 interacts directly with microtubules [J]. Current Biology, 2001, 11 (17) : 1364-1368.
  • 3WATERMAN S C M, SALMON W C, SALMOM E D, et al. Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells[J]. Molecular Biology of the Cell, 2000, 11 (7) : 2471-2483.
  • 4CHAKRABORTY S, MITRA S, FALK M M, et al. E-cadherin differentially regulates the assembly of connexin43 and connexin32 into gap junctions in human squamous carcinoma cells[J]. Journal of Biological Chemistry, 2010, 285(1.4) : 10761-10776.
  • 5BUTKEVICH E, HI]LSMANN S, WENZEL D, et al. Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton[J]. Current Biology, 2004, 14(8): 650-658.
  • 6HUNTER A W, BARKER R J, ZHU C, et al. Zonula occludens-1 alters eonnexin43 gap junction size and organization by influencing channel accretion [J]. Molecular Biology of the Cell, 2005, 16 (12) : 5686-5698.
  • 7LAING J G, MANLEY M R N, KOVAL M, et al. Counexin45 interacts with zonula occludens-1 and counexin43 in osteoblastic ceils[J]. Journal of Biological Chemistry, 2001, 276(25), 23051-23055.
  • 8GILLERON J, CARETTE D, FIOR1NI C, et al. Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners[J]. Communicative & Integrative Biology, 2009, 2 (2): 104-106.
  • 9HUNTERA W, JOURDAN J, GOURDIE R. Fusion of GFP to the carboxyl terminus of Connexin43 increases gap junction size in HeLa cells [J] .Cell Commun Adhes, 2003, 10, 211-214.
  • 10LAING J G, CHOU B C, STEINBERG T H. ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells[J]. Journal of Cell Science, 2005,118(10) : 2167-2176.

同被引文献23

  • 1MOREL S,KWAK B R. Roles of connexins in atherosclerosis andischemia reperfusion injury [ J]. Curr Pharm Biotechnol, 2012, 13(1): 17 -26.
  • 2BIVI N,CONDON K W,ALLEN M R,et al. Cell autonomous re-quirement of connexin 43 for osteocyte survival : consequences forendocortical resorption and periosteal bone formation [ J] . J BoneMiner Res, 2012,27(2) : 374 -389.
  • 3LECANDA F, WARLOW P M, SHEIKH S, et al. Connexin43deficiency causes delayed ossification, craniofacial abnormalities,and osteoblast dysfunction[ J]. J Cell Biol, 2000, 151(4): 931 -944.
  • 4MCLACHLAN E, PLANTE I,SHAO Q, et al. ODDD - linkedCx43 mutants reduce endogenous Cx43 expression and function inosteoblasts and inhibit late stage differentiation [ J ]. J Bone MinerRes, 2008, 23(6) : 928 -938.
  • 5CHAIBLE L M,SANCHES D S,COGLIATI B, et al. Delayed os-teoblastic differentiation and bone development in Cx43 knockoutmice[J]. Toxicol Pathol, 2011,39(7): 1046 -1055.
  • 6BONE WALD L F. The amazing osteocyte [ J ]. J Bone Miner Res,2011 , 26(2) : 229 -238.
  • 7GRIMSTON S K, BRODT M D,SILVA M J, et al. Attenuated re-sponse to in vivo mechanical loading in mice with conditional oste-oblast ablation of the connexin43 gene ( Gjal ) [ J]. J Bone MinerRes,2008,23(6) : 879 -886.
  • 8KITASE Y, BARRAGAN L,QING H,et al. Mechanical induc-tion of PGE2 in osteocytes blocks glucocorticoid - induced apopto-sis through both the p - catenin and PKA pathways [ J]. J BoneMiner Res, 2010, 25(12) : 2657 -2668.
  • 9LI X, LIU C, LI P, et al. Connexin 43 is a potential regulator influid shear stress - induced signal transduction in osteocytes[ J]. JOrthop Res, 2013, 31(12) : 1959 -1965.
  • 10ADACHI T B, AONUMA Y, ITO S I, et al. Osteocyte calciumsignaling response to bone matrix deformation [ J ]. J Biomech,2009,42(15) : 2507 -2512.

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汕头大学医学院学报
2013年 第4期

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