新疆地区人嗜吞噬细胞无形体病的人群血清流行病学调查

A SERO-EPIDEMIOLOGICAL INVESTIGATION ON HUMAN GRANULOCYTIC ANAPLASMOSIS IN XINJIANG

为了解人嗜吞噬细胞无形体病在新疆地区的流行状况，本研究采集和硕、石河子、博乐三地区居民与农林牧工作者血液样本，利用间接免疫荧光法对嗜吞噬细胞无形体特异性IgG滴度水平进行检测，对结果进行统计学分析。共检测血清442份，平均阳性率43．7％（193／442），其中和硕、石河子与博乐地区依次为42．6％（55／129），35．2％（63／179）和56．0％（75／134）。不同地区、不同职业、居住工作所在的生态地理环境中的人群抗体阳性率存在差异（X^2=13．524，P=0．001；X^2=49．129，P=0．000；X^2=14．397，P=0．001），而年龄、性别与民族因素与阳性率差异无关（X^2=8．023，P=0．236，X2=0．778，P=0．378，X^2=6．869，P=0．076）。综上所述，新疆上述三地区中农林牧工人感染嗜吞噬细胞无形体的情况较为普遍。

To understand the infection and prevalence of Human granulocytic anaplasmosis （HGA） in Xinjiang, IgG serum antibodies sampled from populations lived in Heshuo, Shihezi and Bole, were determined with indirect immunofluorescence assay （IFA）. The subjects were divided into groups for sero-epidemiological study according to the area and environment they lived, and age, sex, occupation and nationality. An average positive rate of 43.7% （193/442） was obtained from 442 serum samples, among which 42.6% （55/129） was from Heshuo, 35.2% （63/179） from Shihezi and 56.0% （75/134） from Bole. Significant differences of positive rate existed in different environment and occupation, but no significant difference with different age, sex and nationality. There was a high infection risk of HGA in populations highly occupational exposed to ticks.