摘要
干细胞治疗肝纤维化已取得实质性进展,但是治疗中干细胞自我更新能力下降影响了疗效,因而提高干细胞自我更新能力尤为紧迫和重要,目前研究认为性激素对干细胞的自我更新能力有影响。以性激素作为切入点,综述了雌激素、雄激素对不同干细胞自我更新能力的影响及不同性别来源的干细胞功能上存在的差异,探讨了性激素对干细胞治疗肝纤维化的影响。认为性激素对将来干细胞治疗肝纤维化时提高干细胞自我更新能力,以及选择合适的细胞有重要的理论和临床价值。
Substantial progress has been made in the stem cell therapy for liver fibrosis. However, the therapeutic effect is limited by decreased self - renewal of stem cells during migration. Therefore, to improve the self - renewal of stem cells after transplantation is urgent and essential for the successful application of stem cells in clinical practice. Current studies have shown that sex hormones have an impact on the self - renewal of stem cells. The effects of estrogens and androgens on the self - renewal of various stem cells and the functional differences between the stem cells from persons of different sexes are reviewed. Moreover, the effect of sex hormones on stem cell therapy for liver fibro- sis is discussed. It is considered that sex hormones have significant theoretical and clinical values for improving the self - renewal of stem cells and selecting appropriate stem cells in the stem cell therapy for liver fibrosis.
出处
《临床肝胆病杂志》
CAS
2014年第1期82-85,共4页
Journal of Clinical Hepatology
