宫颈癌中ErbB-2与Ebp1蛋白的表达与临床病理特征的关系及其临床意义

Relationship and its clinical significance between expression of ErbB-2 and Ebp1 proteins in cervical cancer

[目的]观察ErbB-2与Ebp1蛋白在宫颈癌组织中的表达,并探讨其与宫颈癌临床病理特征的关系及意义.[方法]应用免疫组织化学方法分别检测30例宫颈癌组织及其癌旁组织中ErbB-2与Ebp1蛋白的表达水平.[结果]宫颈癌组织中ErbB-2与Ebp1蛋白的表达水平明显高于癌旁组织(P<0.05),宫颈癌组织中ErbB-2与Ebp1蛋白表达与患者年龄、肿瘤分化程度、家族史无关,ErbB-2与Ebp1蛋白高表达与肿瘤的TNM分期以及淋巴结转移呈正相关(P<0.05).[结论]ErbB-2联合Ebp1蛋白检测有助于宫颈癌转移及预后的判断,Ebp1有望成为宫颈癌基因治疗的生物学靶点.

OBJECTIVE To study the relationship and its clinicopathologlcal slgnltlcance oetween expression of ErbB-2 and Ebpl proteins in cervical cancer. METHODS Expression of ErbB-2 and Ebpl protein in 30 cases of cervical cancer and pericarcinomatous tissue were detected by immunohistochemistry. RESULTS The expression of ErbB-2 and Ebpl were significantly higher in cervical cancer than in pericarcinomatous tissue （P〈0.05）, and had no related to age, tumor differentiation and family tumor history of patients, but the overexpression of ErbB-2 and Ebpl had positive correlation with the TNM staging and lymphatic metastasis （P 〈 0.05）. CONCLUSION The combined detection of expression of ErbB-2 and Ebpl in cervical cancer is helpful to estimate of metastasis and prognosis, and the Ebpl is hopeful to be one of biological targets in tumor immunotherapy for cervical cancer.