延边农村地区成人空腹血糖受损与多种代谢异常的相关性

Correlation between impaired fasting glucose and multiple metabolic disorders in adults of Yanbian rural area

[目的]分析延边农村地区朝鲜族和汉族人群空腹血糖受损与多种代谢异常的相关性．[方法]在延边农村地区随机选择2个自然村，采用整群抽样的方法抽取3217人作为研究对象，年龄在30～70岁之间．通过问卷的方式收集研究对象的一般情况，内容包括调查对象的性别、年龄、民族、职业等一般情况、饮食、吸烟、饮酒、疾病家族史及本人既往史．通过体格检查的方式，测定体质量指数（BMI）、腰围（WC）、血压（BP）、空腹血糖（FBG）、三酰甘油（TG）、高密度脂蛋白－胆固醇（HDL—C）、血尿酸（UA）、谷氨酰转移酶（GGT）及胰岛素（FINS）等代谢指标．按照GGT，UA及胰岛素抵抗指数（HOMA－IR）、胰岛B细胞分泌指数（HOMA-β）、胰岛素敏感性指数（ISI）水平四分位数把研究对象分为4组后进行分析．[结果]整体型肥胖、腹型肥胖、高血压、高三酰甘油血症、低HDL-C血症组的空腹血糖升高（IFG）患病率显著高于血糖正常组（P〈0．05），且随着BMI水平的增高，IFG的检出率有升高的趋势（P〈0．001）．GGT四分位点的IFG检出率分别为11．2％，13．1％，17．3％，18．0％，UA分别为11．2％，15．1％，13．3％，19．5％，HOMA．IR分别为7．2％，11．3％，10．6％，33．2％，HOMA-β分别为24．7％，17．8％，13．5％，4．9％，ISI分别为33．2％，10．6％，11．3％，7．2％，升高或降低趋势均有统计学意义（P〈0．001）．[结论]不同代谢异常组IFG检出率显著高于代谢正常组，GGT，UA，HOMA-IR，HOAM-β及ISI对IFG患病危险的影响具有剂量反应关系．

OBJECTIVE To analyze the correlation between impaired fasting glucose （IFG） and multiple metabolic disorders in Korean-Chinese and Han nationality adults of Yanbian rural area. METHODS 2 natural villages were randomly chose in rural areas, and 3 217 adults, 30- 70 years old, were selected by the cluster sampling method. The general information of subjects were collected by questionnaire, including gender, age, nationality, occupation, diet, smoking, drinking, past history and family history. BMI, waist circumference, BP, FBG, TG, HDL-C, blood uric acid （BUA）, gamma-glutamyl transferase （GGT） and fasting insulin （FINS） were measured by physical examination. According to the quartiles of GGT, UA, HOMA-IR, HOMA-β and ISI, all of subjects were divided into four subgroups and analyzed. RESULTS The prevalence of overall obesity, central obesity, hypertension, high TG and low HDL-C were significantly higher in IFG group than in normal FBG group, and prevalence of IFG was increased along with increase of BMI （P〈0. 001）. The prevalence of IFG according to the GGT quartiles was 11.2%, 13.1%, 17. 3 % and 18.0%, the UA was 11.2%, 15. 1%, 13.3% and 19. 5%, the HOMA-IR was 7. 2%, 11.3%, 10. 6% and 33.2%, the HOMA-β was 24.7%, 17.8%, 13.5% and 4.9%, and the ISI was 33.2%, 10.6%, 11.3% and 7.2%, respectively, and that was increased along with increase of GGT, UA and HOMA-IR, and decreased along with decrease of HOMA-β and ISI （P〈0. 001）. CONCLUSION The prevalence of IFG in the group with different metabolic disorder is significantly higher than that in normal metabolic group, and the risk factors of IFG have dose-response relationship with the GGT, UA, HOMA-IR, HOMA-β and ISI.