脑白质纤维束跟踪算法的研究进展

Advance in the study of white matter tractography

基于弥散张量成像(diffusion tensor imagine,DTI)技术的脑白质纤维跟踪(white matter tractography,WMT)是目前唯一非入侵式三维重建活体脑白质纤维束解剖结构的方法,有助于深入了解人脑白质纤维的微观结构,对神经生理研究和临床应用也有较大价值,成为神经纤维成像技术的研究热点之一。本文在DTI原理的基础上,归纳总结了近几年来比较有代表性的几类脑白质跟踪算法,重点分析了其跟踪原理、优点和局限性,并介绍了脑白质跟踪算法的应用情况,同时对今后的研究发展进行了展望。

White matter tractography （WMT） based on diffusion tensor imaging （DTI） is the only available technique for the 3D reconstruction of white matter micro-architecture non-invasively and in vivo. It is very important for the neurophysiological research and clinical works. In this article, several algorithms of white fiber tractography are reviewed, including their advantages and limitations on the basis of the principle of tracking. At the same time, the applications of WMT are introduced. Finally, future research and development of WMT are also discussed.