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丙酮酸激酶M2型(PKM2)入核机制和核内作用的研究进展 被引量：4

A review of the mechanism of pyruvate kinase M2′s nuclear translocation and its function in nucleus
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摘要 传统观点认为丙酮酸激酶M2型(pyruvate kinase M2,PKM2)通过催化肿瘤细胞糖代谢来促进肿瘤细胞生长。近年来研究发现除了酶催化功能外,PKM2还能通过多种途径进入细胞核,在核内作为蛋白激酶广泛参与转录调控、蛋白修饰等过程。本文将就这方面的研究成果作一综述。 Conventional views states that the pyruvate kinase M2 （PKM2） enhances the growth of cancer cells via catalying glucose metabolism. However,many recent studies have reaveled that PKM2 can he translocated into nucleus where it functions more vitally than catalying though a variety of ways. As a protein kinase, PKM2 widely participants in transciptional regulation and protein modification in the nucleus. These literatures will be briefly recapitulated in this review.
作者 詹成 时雨 马军 王琳 王群
机构地区 复旦大学附属中山医院胸外科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2014年第1期133-137,共5页 Fudan University Journal of Medical Sciences
基金 高等学校博士学科点专项科研基金(20110071120066) 吴阶平医学基金(320.6750.12300)~~
关键词 丙酮酸激酶M2型(PKM2) 细胞核 糖酵解 pyruvate kinase M2 （PKM2） nucleus~ glucolysis
分类号 Q493.4 [生物学—生理学]
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参考文献24

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同被引文献54

  • 1李华,高国兰.HPV与宫颈癌的研究进展[J].实用癌症杂志,2007,22(4):420-422. 被引量：20
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  • 3Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007; 12(2): 108-13.
  • 4Keller KE, Tan IS, Lee YS. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 2012; 338(6110): 1069-72.
  • 5Wong N, Ojo D, Yan J, Tang D. PKM2 contributes to cancer metabolism. Cancer Lett 2015; 356(2 PtA): 184-91.
  • 6Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 2012; 491(7424): 458- 62.
  • 7Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452(7184): 230-3.
  • 8Brinck U, Eigenbrodt E, Oehmke M, Mazurek S, Fischer G. L-and M2-pyruvate kinase expression in renal cell carcinomas and their metastases. Virchows Arch 1994; 424(2): 177-85.
  • 9Schneider J, Neu K, Grimm H, Velcovsky HG, Weisse G, Eigenbrodt E. Tumor M2-pyruvate kinase in lung cancer patients: Immunohistochemical detection and disease monitoring. Anticancer Res 2002; 22(1A): 311-8.
  • 10Luftner D, Mesterharm J, Akrivakis C, Geppert R, Petrides PE, Wemeeke KD, et al. Tumor type M2 pyruvate kinase expression in advanced breast cancer. Anticancer Res 2000; 20(6D): 5077- 82.

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复旦学报（医学版）
2014年 第1期

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