玻璃酸钠滴眼液联合小牛血去蛋白提取物眼胶对玻切术后泪膜的作用

Effects of sodium hyaluronate eye drops combined with deproteinized calfblood extract eye gel on tear film after vitrectomy

目的:观察玻璃体切除手术后玻璃酸钠滴眼液、小牛血去蛋白提取物眼用凝胶对术后患者泪膜功能恢复的作用。方法:选择玻璃体切除手术后患者120例,随机分为四组,每组30例,A组为常规用药,B组加用玻璃酸钠滴眼液,C组加用小牛血去蛋白提取物眼用凝胶,D组联合加用玻璃酸钠滴眼液和小牛血去蛋白提取物眼用凝胶。分别于术前1d,术后1,3,7,14,30d,观察四组的泪膜破裂时间的检查(break up time,BUT)、基础泪液分泌试验结果(SⅠt),并同时对患者进行不适症状的评价。结果:(1)术后1,3,7,14d,SⅠt和BUT与术前比较差异有统计学意义(P<0.05);术后30d泪膜检查指标基本恢复之前水平。(2)四组治疗方法均可使泪膜功能恢复,但D组的检查指标恢复程度明显优于其他三组。结论:玻璃体切除术后早期联合用玻璃酸钠滴眼液和小牛血去蛋白提取物眼用凝胶可加速泪膜功能的恢复。

AIM： To evaluate tear film recoveries and effects of sodium hyaluronate eye drops, deproteinized calf blood extract eye gel on tear film after vitrectomy. METHODS： In 120 cases after vitrectomy, the patients were randomly divided into four groups, 30 cases for each group, group A were given the conventional medicine, group B in addition to conventional medicine, with sodium hyaluronate eye drops, group C in addition to conventional medicine, with deproteinized calf blood extract eye gel, group D in addition to conventional medicine with sodium hyaluronate eye drops and deproteinized calf blood extract eye gel. Tear break-up time （BUT）, Schirmer I test （S I t） corneal fluorescein staining were measrued at ld preoperatively plus 1,3, 7, 14, 30d postoperatively. The results were analyzed statistically. RESULTS： （1） Statistical significance was found in BUT, Sit at ld preoperatively and 1, 3, 7, 14d postoperatively （P 〈 0. 01 ）; BUT, ST recoveried original level 30d postoperatively. （2） All the four methods could recover fear film, but the result of group D was significantly better than other three groups. CONCLUSION：Sodium hyaluronate eye drops combined with deproteinized calf blood extract eye gel as early aspossible can accelerate the recovery of tear film after vitrectomy.