摘要
目的:研究Bcl-2和Bax在结膜松弛症患者的结膜组织中的表达状况。方法:HE染色观察松弛结膜组织的组织特点,免疫组织化学方法检测20例结膜松弛症患者松弛结膜组织中Bcl-2和Bax的表达状况,并与10例正常结膜组织进行比较。结果:松弛结膜组织鳞状上皮增生间质中有淋巴、浆细胞浸润,Bcl-2在松弛结膜组织中表达与对照组比较差别无显著性意义(P>0.05),Bax在松弛结膜组织中表达明显增加,与对照组比较差别有显著性意义(P<0.05),经Spearman等级相关分析(r=0.432,P>0.05),Bcl-2与Bax阳性表达间无相关性。结论:Bcl-2和Bax表达失衡可能在结膜松弛症的发生和发展中起着重要的作用。
AIM: To study expression conjunctival tissue samples patients. of Bcl-2 and Bax in of conjunctivochalasis METHODS: To observe the histopathological change of conjunctivochalasis by HE staining of conjunctival tissue. Immunohistochemical staining was applied to compare the expression situation of Bcl-2 and Bax in conjunctival tissue of conjunctivochalasis patient (20 samples) and the normal conjunctiva tissue (10 samples). RESULTS: There were lymphocyte and plasmocyte infiltration in the conjunctivochalasis tissue. The expression of Bcl- 2 in the conjunctivochalasis was similar with the normal conjunctiva tissue (P〉0.05). The expression of Bax in the two tissues showed significant difference (P〈0.05). Spearman rank correlation analysis (r= 0. 432, P〉 0. 05) indicated that there was no correlation between the expression of Bcl-2 and Bax. CONCLUSION: Unbalanced expression of Bcl-2 and Bax in conjunctival tissue may play a significant role in the occurrence and development of conjunctivochalasis.
出处
《国际眼科杂志》
CAS
2014年第2期365-367,共3页
International Eye Science
基金
上海市嘉定区科委基金(No.2010023)~~