摘要
目的:研究Bcl-2和Bax在结膜松弛症患者的结膜组织中的表达状况。方法:HE染色观察松弛结膜组织的组织特点,免疫组织化学方法检测20例结膜松弛症患者松弛结膜组织中Bcl-2和Bax的表达状况,并与10例正常结膜组织进行比较。结果:松弛结膜组织鳞状上皮增生间质中有淋巴、浆细胞浸润,Bcl-2在松弛结膜组织中表达与对照组比较差别无显著性意义(P>0.05),Bax在松弛结膜组织中表达明显增加,与对照组比较差别有显著性意义(P<0.05),经Spearman等级相关分析(r=0.432,P>0.05),Bcl-2与Bax阳性表达间无相关性。结论:Bcl-2和Bax表达失衡可能在结膜松弛症的发生和发展中起着重要的作用。
AIM： To study expression conjunctival tissue samples patients. of Bcl-2 and Bax in of conjunctivochalasis METHODS： To observe the histopathological change of conjunctivochalasis by HE staining of conjunctival tissue. Immunohistochemical staining was applied to compare the expression situation of Bcl-2 and Bax in conjunctival tissue of conjunctivochalasis patient （20 samples） and the normal conjunctiva tissue （10 samples）. RESULTS： There were lymphocyte and plasmocyte infiltration in the conjunctivochalasis tissue. The expression of Bcl- 2 in the conjunctivochalasis was similar with the normal conjunctiva tissue （P〉0.05）. The expression of Bax in the two tissues showed significant difference （P〈0.05）. Spearman rank correlation analysis （r= 0. 432, P〉 0. 05） indicated that there was no correlation between the expression of Bcl-2 and Bax. CONCLUSION： Unbalanced expression of Bcl-2 and Bax in conjunctival tissue may play a significant role in the occurrence and development of conjunctivochalasis.
出处
《国际眼科杂志》
CAS
2014年第2期365-367,共3页
International Eye Science
基金
上海市嘉定区科委基金(No.2010023)~~
