PDGF-D与MPO在大肠癌组织中的表达及临床意义

Expression and clinical significance of PDGF-D and MPO in colorectal cancer

目的探讨血小板源性生长因子D(PDGF-D)与髓过氧化物酶(MPO)在大肠癌组织和大肠腺瘤组织中的表达及其临床意义。方法通过免疫组织化学染色法检测大肠癌组织及大肠腺瘤组织中PDGF-D与MPO的表达及其相关性。采用免疫组化染色方法检测88例大肠癌石蜡包埋组织、72例大肠腺瘤组织中PDGF-D与MPO的表达,并分析MPO和PDGF-D的表达与大肠癌临床病理特征的关系。结果大肠癌组织中PDGF-D与MPO阳性表达率分别为85.23%、63.64%,均显著高于大肠腺瘤组织(34.72%、27.78%),差异有统计学意义(P<0.01)。PDGF-D与MPO在大肠癌组织中的表达呈正相关(r=0.29,P<0.05)。结论 PDGF-D与MPO可能参与了大肠癌的启动及发生过程,在大肠癌的发生、发展和转移过程中起着重要作用。

Objective To detect the expression and clinical significance of platelet-derived growth factor D （PDGF- D） and myeloperoxidase （MPO） in colorectal cancer and colorectal adenomas tissues. Methods The expression and relationship of PDGF-D and MPO were detected by immunohistochemistry in colorectal cancer and colorectal adenomas tissues. The expression of PDGF-D and MPO were detected by immunohistochemistry in 88 cases of colorectal cancer, 72 cases of colorectal adenomas, and the relationship of the expression of PDGF-D, MPO with clinical pathological pa- rameters was analyzed in the colorectal cancer tissues. Results The positive rates of PDGF-D and MPO in colorectal cancer were 85.23% and 63.64% , respectively, and both were significantly higher in colorectal cancer tissues than those in eolorectal adenomas tissues （34.72%, 28.56% ）, the difference was statistically significant （P 〈 0. 01 ）. The expression of PDGF-D was positively related to MPO in colorectal cancer tissues （ r = 0. 29, P 〈 0.05 ）. Conclusion PDGF-D and MPO may be involved in the start and process of colorectal cancer, and they play important roles in the process of the occurrence, development and metastasis of colorectal cancer.