期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Furin在宫颈癌变过程中的表达及其临床病理意义 被引量：4

原文传递
导出
摘要 Furin是蛋白前体加工酶家族中的重要成员，与肿瘤的转化、发展与转移密切相关。我们分别检测正常宫颈黏膜、宫颈上皮内瘤变（CIN）及宫颈癌组织中FurinmRNA及蛋白质的表达水平及酶活性，以探讨Furin与宫颈癌变的关系。
作者 张蕾蕾 孙珠蕾 刘强 张艳 景红 吴江
机构地区 河南大学淮河医院病理科 河南大学淮河医院检验科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2014年第1期36-37,共2页 Chinese Journal of Pathology
关键词 宫颈黏膜 临床病理 癌变过程 宫颈上皮内瘤变 宫颈癌组织 前体加工 宫颈癌变 酶活性
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Martin CM,Astbury K,O' Leary JJ. Molecular profiling of cervical neoplasia[J].{H}Expert reviews of Molecular Diagnostics,2006,(2):217-229.
  • 2Thomas G. Furin at the cutting edge:from protein traffic to embryogenesis and disease[J].{H}Nature Reviews Molecular Cell Biology,2002,(10):753-766.
  • 3Anderson ED,VanSlyke JK,Thulin CD. Activation of the furin endoprotease is a multiple-step process:requirements for acidification and internal propeptide cleavage[J].{H}EMBO Journal,1997,(7):1508-1518.
  • 4Bassi DE,Mahloogi H,A1-Saleem L. Elevated furin expression in aggressive human head and neck tumors and tumor cell lines[J].{H}Molecular Carcinogenisis,2001,(4):224-232.
  • 5张萍,庞义,杨波,尹崇.弗林蛋白酶—一种重要的前体蛋白内切蛋白酶[J].生物技术通讯,2002,13(2). 被引量：2
  • 6Poincloux R,Lizárraga F,Chavrier P. Matrix invasion by tumour cells:a focus on MT1-MMP trafficking to invadopodia[J].{H}Journal of Cell Science,2009,(Pt17):3015-3024.
  • 7Bosch FX,de Sanjosé S. Human papillomavirus and cervical cancer:burden and assessment of causality[J].{H}Journal of the National Cancer Institute Monographs,2003,(31):3-13.
  • 8Thomison J 3rd,Thomas LK,Shroyer KR. Human papillomavirus:molecular and cytologic/histologic aspects related to cervical intraepithelial neoplasia and carcinoma[J].{H}Human Pathology,2008,(2):154-166.
  • 9Reshmi G,Pillai MR. Beyond HPV:oncomirs as new players in cervical cancer[J].{H}FEBS Letters,2008,(30):4113-4116.
  • 10Strongin AY. Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy[J].{H}Biochimica et Biophysica Acta,2010,(1):133-141.

二级参考文献21

  • 1Roebroek AJ, Schalken JA, Bussemakers MJ et al. Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene[J]. Mol Biol Rep, 1986, 11 (2): 117
  • 2Fuller RS, Brake AJ, Thomer J. Intracellular targeting and structural conservation of a prohormone-processing endoprotease [J]. Science, 1989. 246 (4929): 482
  • 3Ayoubi TA, Greemers JW, Roebroek Aj et al. Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters[J]. J Biol Chem, 1994, 269 (12): 9298
  • 4Hatsuzawa K, Hosaka M, Nakngawa T et al. Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells [J]. J Biol Chem, 1990, 265 (36): 22075
  • 5Zheng M, Streck RD, Scott RE et al. The developmental expression in rat of proteases furin, PCI, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity[J]. J Neurosci, 1994, 14 (8): 4656
  • 6Anderson ED, VanSlyke JK, Thulin CD et al. Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage[J]. EMBO J, 1997,16 (7): 1508
  • 7Klimpel KR, Molloy SS, Thomas G et al. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin[J]. Proc Natl Acad Sci USA, 1992, 89 (21): 10277
  • 8Tsuneoka M, Nakayama K, Hatsuzawa K et al. Evidence for involvement of furin in cleavage and activation of diphtheria toxin[J]. J Biol Chem, 1993. 268 (35): 26461
  • 9Jones BG, Thomas L, Molloy SS et al. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail[J]. EMBO J. 1995. 14 (23):5869
  • 10Siezen RJ, Creemers JW, Van de Ven WJ. Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases[J]. Eur J Biochem.1994, 222 (2): 255

共引文献1

同被引文献28

引证文献4

二级引证文献15

中华病理学杂志
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部