新疆维吾尔族及汉族帕金森病患者临床症状的比较

Comparison of clinical symptoms for Uygur and Han Parkinson＇s disease patients

目的探讨新疆维吾尔族和汉族帕金森病（PD）患者临床症状特点。方法对2008年6月至2011年9月在新疆乌鲁木齐市及南、北疆收集的91例维吾尔族和173例汉族帕金森病患者采用统一帕金森病问卷、UPDRS评定量表、Hoehn-Yahr分级量表、简易精神状态检查（MMSE）量表、日常生活能力问卷（ADCS．ADL）和神经精神问卷（NPI）进行评定，比较维吾尔族和汉族PD患者临床症状发生的特点。结果维吾尔族和汉族PD患者通过药物治疗者汉族[108例（62．34％）]多于维吾尔族[36例（39．56％），P〈0．05]，但其治疗有效者两组比较差异无统计学意义（P〉0．05）。维吾尔族和汉族患者Hoehn—Yahr分级差异均无统计学意义（均P〉0．05）；Hoehn—Yahr分期维吾尔族和汉族PD患者中重度组比较，ADL、UPDRSII与UPDRSⅢ评分差异均无统计学意义（均P〉0．05）；以静止性震颤＋肌张力增高＋运动迟缓为首发症状维吾尔族[8例（19．05％）]多于汉族[7例（7．07％），P〈0．05]；维吾尔族N型进展者比例[36例（85．71％）]多于汉族[48例（48．48％），P〈0．05]；其他首发症状、首发部位以及开关现象、异动现象两组比较差异均无统计学意义（均P〉0．05）；MMSE评分与NPI评分维吾尔族和汉族差异无统计学意义（P〉0．05）。结论维吾尔族和汉族PD患者典型运动症状、病情严重程度、日常生活能力、认知功能和精神症状均无差异；维吾尔族N型进展者较汉族多；而汉族在以静止性震颤＋肌张力增高＋运动迟缓为首发症状高于维吾尔族。

Objective To explore the characteristics of clinical symptoms in Uygur and Han patients with Parkinson＇s disease （PD）. Methods The unified Parkinson＇s disease rating scale （UPDRS）, Hoehn-Yahr, mini-mental state examination （MMSE） scale, Alzheimer disease cooperative study-activities of daily living （ADCS-ADL） and neuropsychiatric inventory （NPI） were administered to 91 Uygur and 173 Han PD patients from Xinjiang Urumqi and surrounding region from June 2008 to September 2011 to compare the characteristics of clinical symptoms between Uygur and Han patients. Results The subjects of drug treatment in Han [ 108 （62.34%） ] were more than in Uygur [ 36 （39.56%）, （ P 〈 0.05 ） ]. However there were no significant differences in the subjects of effective treatment between two groups （ P 〉 0.05 ）. No significant inter-group differences existed in the scores of Hoehn-Yahr （ P 〉 0. 05 ）. Compare with moderate and severe group in Hoehn-Yahr, there were no significant differences in the scores of ADL, UPDRS II and UPDRS 11[ between two groups （P 〉 0.05）. The subjects of resting tremor, increased muscle tone and bradykinesia as the presenting symptoms in Uygur [ 8 （19.05%）] were more than in Han [ 7 （7. 07% ）, （P 〈 0.05 ） ]. And the subjects of N-type progressive in Uygur [ 36 （85.71%） ] were more than in Han [ 48 （48.48%）, （P 〈 0.05 ）]. There were no significant differences in other presenting symptoms, initial site, on-off phenomenon and dyskinesia between two groups （P 〉 0.05）. No significant differences existed in the scores of MMSE and NPI between two groups （ P 〉 0.05 ）. Conclusion No significant differences exist in typical motor symptoms, severity of disease, activities of daily living, cognitive dysfuntion and psychiatric symptoms between Uygur and Han. But N-type progressive is more common in Uygur. And the presenting symptoms of resting tremor, increased muscle tone and bradykinesia are also higher in Uygur.