期刊文献+

PI3K抑制剂对正常人外周血单个核细胞糖皮质激素抵抗的作用

下载PDF
导出
摘要 慢性阻塞性肺疾病(chronic obstructive pulmonarydisease,COPD)是以气流受限为特征的全身慢性进行性疾病,炎症是重要的发病机制之一,糖皮质激素作为一种有效的抗炎药物,在炎症性疾病的治疗中起着至关重要的作用,但由于COPD患者体内存在糖皮质激素抵抗,使激素对COPD慢性炎症的疗效较差[1]。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第2期195-196,199,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81260012 81160009)
  • 相关文献

参考文献2

二级参考文献57

  • 1Mathers C, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2007; 3: e442.
  • 2Hogg lC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009; 4: 435-459.
  • 3Chung KF, Adcock 1M. Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir 12008; 31: 1334-1356.
  • 4Barnes Pl. Glucocorticosteroids: current and future directions. Br 1 Pharmacol 2011; 163: 29-43.
  • 5Hansel TT, Barnes Pl. New drugs for exacerbations of chronic obstructive pulmonary disease. Lancet 2009; 374: 744-755.
  • 6Rabe KF, Hiemstra PS. Theophylline for chronic obstructive pulmonary disease? .. Time to move on. Am 1 Respir Crit Care Med 2010; 182: 868-869.
  • 7Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA), 2006. (Available from www.ginasthma.org Date last updated, 2006).
  • 8Snow V, Lascher S, Mottur-Pilson C, Joint Expert Panel on Chronic Obstructive Pulmonary Disease of the American College of Chest Physicians and the American College of Physicians-American Society of Internal Medicine. Evidence base for management of acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 200 I; 134: 595-599.
  • 9Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock 1M, et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002; 99: 892-8926.
  • 10Cazzola M, Page CP, Calzetta L, Matera MG. Emerging anti-inflammatory strategies for chronic obstructive pulmonary disease. Eur Respir 1 2012; 40: 724-741.

共引文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部