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干燥综合征相关性细胞因子 被引量：13

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摘要 干燥综合征(SS)是一种慢性全身性炎症性自身免疫病,主要侵犯泪腺、唾液腺等外分泌腺。近年来,细胞因子在干燥综合征的发生发展中所起的作用引起了关注。Th1/Th2失衡抑制免疫细胞的凋亡,使细胞内累积大量免疫原性核小体,刺激T细胞产生自身抗体,加重自身免疫反应。Th17/Treg失衡可能诱发或加剧SS的发生发展。B细胞反应性增生产生大量细胞因子、免疫球蛋白及多种自身抗体,导致局部组织炎症损伤。SS患者唾液腺及血清中B细胞活化因子(BAFF)水平均较高,并与炎症活动及损害程度相关。趋化因子及其受体在SS炎性细胞迁移至病灶腺体及促进异位生发中心形成的过程中起重要作用。
作者 许满秀 钱先
机构地区 南京中医药大学第一临床医学院 江苏省中医院风湿病科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第2期206-208,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81273714) 江苏省自然科学基金(BK201187)
关键词 干燥综合征 细胞因子 TH1 Th2漂移 THL7 Treg失衡 BAFF FLT3-L
分类号 R392.11 [医药卫生—免疫学] R442.8 [医药卫生—诊断学]
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参考文献26

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二级参考文献47

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共引文献46

同被引文献133

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引证文献13

二级引证文献74

细胞与分子免疫学杂志
2014年 第2期

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