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红藻氨酸致癫痫大鼠外周血调节性T细胞数量与癫痫发作程度相关性研究 被引量：1

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摘要 癫痫（epilepsy）是以神经元反复过度同步异常放电为特征的中枢神经系统综合征，其发病机制尚未完全阐明。研究表明，癫痫的发病机制与机体的神经免疫系统功能紊乱有密切关系。CD4＋CD25＋调节性T细胞（regulatoryTceils，Treg）是一类具有免疫抑制功能的细胞亚群，在神经系统疾病中存在Treg的异常。癫痫患儿外周血Treg增加，目前仍未见Treg数量与癫痫发作程度相关的报道。因此本研究用流式细胞术对红藻氨酸（kainicacid，KA）致大鼠癫痫模型外周血CD4＋CD25＋Treg进行测定，探讨其数量变化与癫痫发作程度的相关性。
作者 牛廷献 马建霞 罗晓红 王红义 冯小明
机构地区 兰州军区兰州总医院动物实验科 兰州军区兰州总医院 兰州石化总医院药剂科 兰州军区兰州总医院内分泌科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第3期281-283,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 甘肃省自然科学基金(1010RJZA052)
关键词 红藻氨酸 癫痫 CD4+CD25+调节性T细胞
分类号 R392.11 [医药卫生—免疫学] R742.1 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

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共引文献10

同被引文献49

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细胞与分子免疫学杂志
2014年 第3期

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