万古霉素在199例儿科患者中的临床应用调查

Investigation of the Clinical Application of Vancomycin in Children

目的:了解我院万古霉素的临床应用情况,分析其合理性。方法:回顾性调查分析我院2012年6月至2012年11月住院患儿的万古霉素用药情况。结果:199例患儿平均住院时间为78 d,其中感染性疾病以肺炎及败血症多见,共占65.33%。199例患儿中有194例进行了病原学检查,有84例行血药浓度监测,有96例联用抗菌药物,发生不良反应6例。结论:万古霉素在我院儿科的应用存在不合理现象,应严格把握适应证,进一步规范万古霉素的使用,以提高万古霉素的治疗效果,减少药物不良反应。

Objective： To investigate the clinical application of vancomycin in our hospital, and to analyze its rationality. Methods： Retrospectively study the application of vancomycin on hospitalized children in our hospital from June 2012 to November 2012. Results： One hundred and ninety-nine cases using vancomycin included in the study and the average length of hospital stay was 78 days. Among them, most of the infections were pneumonia and septicemia, taking up a total of 65.33%. 194 cases of 199 were took pathogenic examinations; 84 cases had therapeutical drug monitoring; 96 cases were used combination antibiotics; 6 cases had adverse reactions. Conclusions： There are still some deficiencies of the application of vancomycin in our hospital. Doctors should strictly master the indications, further standardize the use of vancomycin, and improve the therapeutic efficacy of vancomycin and the level of rational drug use.