头孢硫脒与蒙脱石对小儿急性感染性腹泻的临床疗效

Clinical efficacy of cefathiamidine and montmorillonite in children with acute infectious diarrhea

目的探讨头孢硫脒联合蒙脱石对小儿急性感染性腹泻的临床疗效。方法选取我院儿科住院的173例急性感染性腹泻患儿,采用随机数字表法分为治疗组95例和对照组78例。对照组静脉滴注头孢硫脒,治疗组在对照组基础上口服蒙脱石散。比较两组患儿的临床疗效,临床症状消失时间,以及血清NO、IgG、IgA、IgM水平变化。结果治疗组总有效率为94.74%,对照组为74.36%,治疗组总有效率明显高于对照组(χ2=15.898,P<0.05);治疗组腹痛减轻有效率为86.32%,明显高于对照组(71.79%),两组比较差异有统计学意义(χ2=5.858,P<0.05)。治疗组止泻、退热以及体征好转时间均显著低于对照组,两组比较差异有统计学意义(t=4.419、2.436、11.147,P<0.05);治疗后,治疗组血清NO水平明显低于对照组,两组比较差异有统计学意义(t=8.724,P<0.05);血清IgG、IgA水平显著高于对照组(t=3.795、12.355,P<0.05)。结论头孢硫脒联合蒙脱石治疗小儿急性感染性腹泻疗效确切,不仅能降低治疗时间,还能提高患儿的自身免疫功能,值得临床推广应用。

Objective To explore the clinical efficacy of cefathiamidine combined with montmorillonite in children with acute infectious diarrhea. Methods 173 cases of children with acute infectious diarrhea in our hospital were selected and randomly divided into treatment group （ n = 95 ） and control group （ n = 78 ） ; the control group re- ceived intravenous infusion of cefathiamidine, and the treatment group received oral montmorillonite powder based on the control group. The clinical effect, clinical symptoms disappearing time and serum NO, IgG, IgA, IgM changes of the two groups were compared. Results The total effective rate of treatment group （94. 74% ） was significantly higher than that of control group （ 74. 36% ） , there was significant difference between the two groups （A3 = 15. 898, P 〈 0. 05 ）. The rate of relieving bdominal pain of treatment group （86. 32% ） was significantly higher than that of control group （71.79%） ,there was significant difference between the two groups （Aft =5. 858 ,P 〈0. 05）. Diarrhea,fever and signs recovery time of treatment group was significantly lower than that of the control group, there was significant difference between the two groups （ t = 4. 419,2. 436,11. 147, P 〈 0. 05 ）. After treatment, the serum level of NO of treatment group was significantly lower than that of control group, there was significant difference between the two groups （ t = 8. 724, P 〈 0.05 ）, the serum IgG, IgA levels of treatment group were significantly higher than those of con- trol group （ t = 3. 795,12. 355, P 〈 0.05 ）. Conclusion Cefathiamidine combined with montmorillonite in the treatment of children with acute infectious diarrhea can not only reduce the treatment time ,but also improve the immune function in children, it is worthy of clinical application.