氧驱雾化吸入普米克令舒治疗小儿哮喘急性发作疗效及对肺功能的影响

Effect and impact on pulmonary function of pulmicort in the treatment of acute asthma attacks in children by oxygen drive inhalation

目的观察普米克令舒治疗小儿哮喘急性发作的疗效及对肺功能的影响,为小儿哮喘的临床防治提供参考。方法将108例哮喘急性发作患儿随机分为2组。A组53例,给予止咳、祛痰、平喘、纠正水电解质紊乱、抗感染及吸氧等对症支持治疗;B组55例,在此基础上加用普米克令舒氧驱雾化吸入治疗,观察两组临床症状缓解时间及肺功能改变。结果 A组总有效率为81.13%,B组总有效率为94.54%,两组比较差异有统计学意义(P<0.05);B组喘憋、咳嗽、肺部哮鸣音缓解时间分别为(2.9±0.6)d、(3.1±1.1)d、(3.6±1.1)d,短于A组的(3.7±0.4)d、(4.2±1.3)d、(5.1±1.4)d,两组比较差异有统计学意义(P<0.05);治疗1周后,B组第1秒用力呼气容积(FEV1)、最大呼气峰流速(PEF)、用力肺活量(FVC)分别为(2.38±0.31)L、(192.5±24.2)L/min、(1.45±0.61)L,大于A组的(2.05±0.30)L、(176.8±25.3)L/min、(1.12±0.46)L,两组比较差异有统计学意义(P<0.05)。结论雾化吸入普米克令舒治疗小儿哮喘急性发作,可有效缓解喘憋、咳嗽等症状,改善肺功能。

Objective To observe the effect and impact on pulmonary function of pulmicort in the treatment of acute asthma attacks in children by oxygen drive inhalation, and provide a reference for the prevention and treatment of asthma in children. Methods 108 cases of acute asthma attacks children were randomly divided into 2 groups, 53 cases in group A were given cough, phlegm, asthma, correct water and electrolyte imbalance, anti-infective, oxygen and other symptomatic and supportive therapy, while 55 cases in group B,related with pulmicort by oxygen drive inhalation on the basis of treatment of group A. clinical symptoms and lung function change of the two groups were observed. Results The total effective rate of group B （ 94. 54 % ） was higher than that of group A （ 81. 13 % ）, there was signifi- cant difference between the two groups （ P 〈 0. 05 ） ; the wheezing, coughing, wheezing lungs mitigation time were （2.9±0.6）d,（3.1±1.1）d,（3.6±1. 1）dingroup B and （3.7±0.4）d,（4.2±1.3）d,（5. 1±1.4）din group A, there were significant differences between the two groups （P 〈0. 05） ;After 1 week,FEV1 ,PEF,FVC levels of group B were more than these of group A [ （ 2. 38 ±0. 31 ） L vs. （ 2.05±0. 30 ） L, （ 192. 5± 24. 2 ） L/min vs. （ 176. 8 ± 25.3 ） L/rain, （ 1.45 ±0. 61 ）L vs. （ 1. 12±0. 46）L] ,there were significant differences between the two groups （P 〈0. 05）.Conclusion Inhalation pulmicort in the treatment of children with acute asthma attacks, can relieve wheezing, coughing and other symptoms effectively, and improve lung function.