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调节性T细胞在器官移植免疫耐受中的研究进展 被引量：2

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摘要 随着器官保存技术、移植手术方式的发展及免疫抑制剂不断研发,器官移植已成为一种挽救终末期脏器衰竭患者生命的有效治疗方式.国外研究表明,目前采用的免疫抑制剂疗法并不能完全防止长期免疫进程中移植物排斥的发生[1],由此所致的慢性移植物失功大大降低了患者移植后的存活期限,且长期应用免疫抑制剂可导致感染、恶性肿瘤等并发症的发生率升高,因此在供体器官严重短缺的今日,如何诱导机体免疫耐受以建立长期稳定的移植物耐受状态,同时规避服用免疫抑制剂所致的不良反应成了亟待解决的问题.
作者 唐韵成 曾强 窦剑
机构地区 河北医科大学第三医院肝胆外科
出处 《器官移植》 CAS CSCD 2014年第1期54-56,共3页 Organ Transplantation
基金 河北省医学科学重点课题计划项目(20130220)
关键词 器官移植 调节性T细胞 免疫耐受
分类号 R617 [医药卫生—外科学]
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参考文献28

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同被引文献23

  • 1HerreroJI. De novo malignancies following liver transplantation: impact and recommendations[J]. Liver Transpl, 2009, 5 (Suppl 2): S90-S94.
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  • 3PonsJA, Ramirez P, Revilla-Nuin B, et aL Immunosuppression withdrawal improves long-term metabolic parameters, cardiovascular risk factors and renal function in liver transplant patients[J] Clin Transplant, 2009, 23 (3): 329-336.
  • 4Caine RY, Sells RA, PenaJR, et a1. Induction of immunological tolerance by porcine liver allografts[J] . Nature, 1969, 223 (5205): 472476.
  • 5GugenheimJ, Samuel D, Reynes M, et al, Liver transplantation across ABO blood group barriers[J] . Lancet, 1990, 336 (8714): 519-523.
  • 6Starzl TE, Demetris AJ, Trucco M, et a1. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance[J]. Hepatology, 1993, 17 (6): 1127-1152.
  • 7Ponton C, Vizcaino L, Tome S, et al. Improvement of renal function after conversion to mycophenolate mofetil combined with low-level calcineurin inhibitor in liver transplant recipients with chronic renal dysfunction[J] . Transplant Proc, 2010, 42 (2): 656-659.
  • 8Tryphonopoulos P, Ruiz P, Weppler D, et al, Long-term follow-up of 23 operational tolerant liver transplant recipients[J] Transplantation, 2010, 90 (12): 1556-1561.
  • 9Benitez C, Londono MC, Miquel R, et a1. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients[J] . Hepatology, 2013, 58 (5): 1824-1835.
  • 10Ohe H, Waki K, Y oshitomi M, et a1. Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match[J]. Transpl Int, 2012, 25 (1): 97 -106.

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器官移植
2014年 第1期

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