生后发育早期甜味经历影响老年甜味偏好

Age-Related Changes of Sweet Taste Preference is Modified by Early Sweet Experience

哺乳期给予母鼠不同浓度AK糖饮水暴露,子代小鼠通过母鼠乳汁获得AK味觉经历.子鼠成年后分别在2个月和12个月大时,双管喜好测试检测小鼠对AK糖溶液的偏好变化.结果显示,早期高浓度的甜味剂经历提高了小鼠成年和老年时AK偏好阈值,降低了小鼠老年时在阈值附近浓度上的偏好分数;同时早期AK经历抑制了正常小鼠在衰老过程中甜味偏好的下降.因此,早期味觉经历影响小鼠在成年和老年时期的甜味偏好,并在一定程度上影响小鼠在衰老过程中的甜味偏好变化.

Mice were exposed to acesulfame-K （AK）via maternal milk from the mother mice during lactation, and two- bottle preference tests for AK solution were performed in 2 and 12 months old. Results indicated that early strong intensity of sweet tastant experience increased the preference threshold and induced a reduction of preference scores about preference thershold at aged stage. Meanwhile,early AK experience inhibited the decrease of preference scores as that in the control animals during the advanced aging. Therefore early taste experience influence the sweet preference at adult and aged stage and modify the sweet preference during the aging process.