摘要
肠易激综合征的发病机制目前尚未完全阐明。胃肠动力异常和内脏高敏性是其主要的病理生理学基础。脑肠肽的异常表达可通过影响内脏感觉、分泌和运动,导致肠易激综合征发生。本文从5-羟色胺、促肾上腺皮质激素释放因子、血管活性肠肽、P物质、生长抑素等脑肠肽入手,探讨脑肠肽与肠易激综合征的相关性,为明确肠易激综合征的发病机制提供参考依据。
The pathogenesis of irritable bowel syndrome(IBS) has not been fully elucidated. Abnormal gastrointesti-nal dynamics and visceral hypersensitivity were its main pathophysiological basis. Abnormal expression of neu-ropeptides can affect the visceral sensation, secretion and movement, leading to the occurrence of IBS. This article reviewed the relationship between neuropeptides and IBS from the following neuropeptides: 5-hydroxytryptamine (5-HT), corticotropin releasing factor (CRF), vasoactive intestinal peptide (VIP), substance P (SP), and somatostatin (SS). It provided reference evidences for the elucidation of IBS pathogenesis.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第8期1747-1750,共4页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81073132):缬草醚醛对肠易激综合征(IBS)的治疗作用及5-HT通路调控的实验研究
负责人:闫兴丽
北京中医药大学校级自主课题(2013JYBZZXS102):蜘蛛香提取物对肠易激综合征(IBS)5-HT通路肠嗜铬细胞
5-羟色胺转运体表达的调控作用研究
负责人:史瑞瑞
关键词
肠易激综合征
脑肠肽
研究进展
Irritable bowel syndrome
neuropeptides
research progress