摘要
目的:优选复方大黄灌肠液提取工艺。方法:基于大黄灌肠液组方原则,兼顾芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚和枸橼酸主要指标成分含量和水溶性总煎出物,以加水量、浸泡时间、提取时间和提取次数为考察因素,采用多指标综合评分法,利用正交试验优选复方大黄灌肠液提取工艺条件。结果:最佳提取工艺为加水量为6倍,浸泡10 min,提取60 min,提取3次。结论:该工艺合理可行,稳定可控,可用于制剂的实际生产。
This study was aimed to optimize extraction techniques of Compound Rhubarb Enema. Based on the for-mula principle of Compound Rhubarb Enema, effects of the amount of water, soaking time, extraction time and fre-quency on each index were studied. The content of Aloe-emodin, Rhein, Emodin, Chrysophanol, Physcion, Citric acid, and water soluble substance were taken into consideration. The best extraction condition was optimized by using the orthogonal test coupled with the multi-index comprehensive evaluation. The results showed that the best condi-tion was soaking for 10 min, extraction time for 60 min, extraction for 3 times; and 6 times of water was added. It was concluded that this preparation techniques were feasible and reliable for the manufacturing process of Compound Rhubarb Enema.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第8期1825-1830,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
广西壮族自治区中医药管理局医院制剂类课题(GZYZ-10-10):大黄灌肠液的研制
负责人:伍小燕
关键词
复方大黄灌肠液
层次分析法
多指标综合评分法
提取工艺
正交试验
Compound Rhubarb Enema
analytic hierarchy process
multi-index comprehensive evaluation
extraction techniques
orthogonal test
