摘要
中药是现代药物的重要组成部分,应用现代分析技术鉴别中药材的真伪、评价质量的优劣,是中药现代化、国际化发展的重要内容。本文介绍了1H-NMR代谢组学技术的发展和特点,以及在中药品种鉴定、道地药材评价、炮制加工、适宜采收期等研究中的应用。并在课题组前期研究基础上,对中药质量评价的1H-NMR代谢组学研究的技术方法、关键问题进行了详细的论述,为中药等天然药物的品种鉴定与质量评价提供了方法学参考。
Traditional Chinese medicine （TCM） is an important part of modem medicine. Application of modem ana- lytical techniques to identify the authenticity of TCM and evaluate its quality is an important and critical content inthe process of the modernization and internationalization of TCM. This paper described the development and charac- teristics of a 1H-NMR-based metabolomics technology, and reviewed its application in the species identification, quality evaluation of “Daodi Yaocai” （i.e., genuine medicinal materials）, processing theory and the best harvest time of TCM. Besides, based on previous work, further discussion was given on technical methods and key question of the 1H-NMR metabolomics method. This paper provided a methodological reference for the species identification and quality evaluation of TCM and other herbal medicines.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第9期1862-1870,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委青年基金项目(81303310):基于DNA条形码和1H-NMR代谢组学技术的多基源藏药小檗皮二维鉴定体系的构建
负责人:范刚
四川省教育厅四川省省属高校科研创新团队建设计划(11TD004):中藏药资源保护与利用
负责人:张艺
关键词
中药
1H-NMR代谢组学
品种鉴定质量评价
Traditional Chinese medicine, 1H-NMR, metabolomics, species identification, quality evaluation
