血清内脂素、白介素6与非酒精性脂肪性肝病关系的研究

The study of the relationship between the levels of serum visfatin,IL-6 and insulin resistance in the patients with nonalcoholic fatty liver disease

目的探讨内脂素、白介素6与非酒精性脂肪性肝病(NAFLD)和胰岛素抵抗(IR)的关系。方法测定60例NAFLD患者及50例健康对照者的空腹血糖(FPG)、空腹胰岛素(FIns)、内脂素(visfatin)、白介素6(IL-6)浓度,计算胰岛素抵抗指数(HOMA-IR)。结果 NAFLD组患者血清内脂素、白介素6水平均高于对照组(P<0.05);两者与胰岛素抵抗指数呈明显正相关(P<0.05),且血清内脂素水平与白介素6水平呈正相关(P<0.05)。结论血清内脂素、白介素6通过与IR相关参与NAFLD的发生和发展。

To investigate the relationship between serum visfatin, IL-6 and insulin resistance in the patients with NAFLD. Methods FPG,FINS,serum visfatin and IL-6 of 60 NAFLD patients and 50 healthy people were measured. Homeostasis model assessment was applied to assess the status of insulin resistance index（HOMA-IR）. Results The levels of serum visfatin and IL-6 of NAFLD group were higher than control group（P〈0.05）. And correlation analysis showed that serum visfatin and IL-6 were all significantly correlated with HOMA-IR,while they were also significantly correlated with each other. Conclusion The levels of serum visfatin and IL-6 may be involved in the development of steatohepatitis and liver fibrosis through the relationship with insulin resistance.