子宫体注射卡前列素氨丁三醇在预防产后出血中的应用价值

Clinical significance of romethamine by uterine body injection for the prevention of postpartum hemorrhage in effect discussion of pregnant women with postpartum bleeding risk factors

目的探讨宫体注射卡前列素氨丁三醇在预防产后出血高危因素孕妇产后出血中的临床疗效。方法选择94例行剖宫产术且有产后出血倾向的高危孕妇,随机平均分为两组,两组均在胎儿娩出后常规宫体注射缩宫素,在此基础上,研究组(47例)给予宫体注射卡前列素氨丁三醇治疗,对照组(47例)给予米索前列醇、垂体后叶素治疗。比较两组产妇产后2、24h出血量及产后出血发生率、输血率、止血时间、近远期并发症发生率。结果研究组产妇产后2、24h出血量及产后出血发生率、输血率、止血时间、子宫切除率均低于对照组,组间比较差异均有统计学意义(P<0.05)。结论对有产后出血倾向的高危孕妇预防性宫体注射卡前列素氨丁三醇,能明显减少产后出血量,降低产后出血发生率和输血率,缩短止血时间,减少近远期并发症,值得临床推广应用。

Objective To explore the clinical significance of romethamine by uterine body injection for the pre-vention of postpartum hemorrhage in effect discussion of pregnant women with postpartum bleeding risk factors . Methods A total of 94 pregnant women with high-risk postpartum bleeding ,underwent cesarean section ,were ran-domly divided into two groups .Cases in both of the two groups were given conventional uterine body injection of oxy-tocin .Then ,the 47 cases in study group were given romethamine ,the 47 cases in control group were given misopros-tol and pituitrin for treatment .Amount of bleeding 2 and 24 hours after delivery ,incidence rate of postpartum hemor-rhage ,incidence rate of blood transfusion ,time to stop bleeding and incidence rate of short and long term complica-tions were compared .Results The amount of bleeding ,incidence rate of postpartum hemorrhage ,incidence rate of blood transfusion ,time to stop bleeding and incidence rate of hysterectomy in study group were significantly lower than control group ,with significant difference （ P 〉 0 .05 ） .Conclusion Preventive uterine body infection of romethamine in high-risk pregnant women with postpartum bleeding tendency could significantly reduce the amount of postpartum hemorrhage ,reduce the incidence rate of postpartum hemorrhage and blood transfusion ,shorten the time to stop bleeding ,and reduce the short and long term complications ,which might be worth for clinical populariza-tion .