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血管抑制因子-1对冠心病的影响及其作用机制 被引量：2

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摘要 嗜铬蛋白A(chromogranin A)是一种神经内分泌系统释放的糖蛋白,它作为多种活性肽的前体参与心血管系统功能的调控。血管抑制因子-1(vasostatin-1)是嗜铬蛋白A酶解后产生的一种具有生物学活性的肽段,在心血管系统中具有抗炎,促进血管舒张,维持血管内皮稳态等一系列保护作用。这些作用可能与一氧化氮(NO)的生成以及抑制丝氨酸/苏氨酸蛋白激酶(P38)信号通路的激活等有关。该文主要介绍vasostatin-1在冠心病中的作用及其可能机制。
作者 熊伟昕 陆林 陶蓉
机构地区 上海交通大学医学院附属瑞金医院心脏科
出处 《国际心血管病杂志》 2014年第1期18-20,共3页 International Journal of Cardiovascular Disease
关键词 嗜铬蛋白A 血管抑制因子-1 血管舒张 内皮细胞
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献18

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同被引文献28

  • 1崔晓敬,孟磊,丁文惠.血管抑制因子的心血管效应和病理生理意义[J].生理科学进展,2013,44(6):429-432. 被引量：1
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  • 3Browning DJ ,Roberg MH. Vitreous. hemorrhage complicating la- ser-induced chorioretinal anastomosis tbr central vein ocelusinn [J]. Am J Ophthalmol,1996,122(4) :588-658.
  • 4Ohno-Matsui K, Morila 1 , Tombrau-Tink .I , el al. Novel mecha- nism for age-related macular degeneration : an equilibrium shill between the angiogenesis factors VEGF and PEDF [ J ]. J Cell Physiol,2001 , 189(1):323-333.
  • 5Lambert HM. The management of subfocveal choroidal neovasculari- zation membranes hemorrhage[ J]. Semin Ophthalmol , 2000, 15 ( 1 ) :92-99.
  • 6Shu Q, Li W,Li H , et al . Vasoslatin inhibits VEGF-induced en- dothelial cell proliferation, tube formation and induces cell apopto- sis under oxygen deprivation[ J ]. lwt J Mol Sci. ,2014 , 15 ( 4 ) : 6019-6030.
  • 7Ramella R, Bocro O, Alloatti G,et al . Vasostatinl activates eNOS in endothelial cells through a proteoglycan-dependent mechanism [J]. J Cell Biochem, 2010,110 (1):70-79.
  • 8Dondossola E,Gasparri A, Bachi A, et al . Role of vasostatin-I C- terminal region in fibroblast cell adhesion . Cellular Molecular Life Sciences ,2010 ,67 ( 12 ) :2107-2018.
  • 9Peng XC,Wang M,Chen XX, et al . Plasmid-encoding vasostatin inhibited the growth and metastasis of human hepatocellular carci- noma cells [J]. Mol Cell Biochem, 2014 ,395(1-2) :265-272.
  • 10Cichofi T, Jarosz M, Smolarczyk R, et al . Vasostatin increases oxy- genation of B16-F10 melanoma tumors and raises therapeutic effi- cacy of cyclophosphamide. Acta Biochim Pol , 2012,59 ( 3 ) : 377-381.

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国际心血管病杂志
2014年 第1期

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