摘要
粒细胞集落刺激因子(G-CSF)对心脏有直接保护作用,也可以通过刺激骨髓干细胞动员至外周血,间接发挥作用,加速损伤修复,减少心血管不良事件。近年来涌现出大量关于G-CSF在心血管疾病方面的临床研究文章,G-CSF使用的剂量、时机、疗程、联用药物等均会影响治疗效果,本文总结了国内外的研究结果,可为G-CSF在心血管疾病方面进一步的临床应用提供依据。
In addition to directly protecting the heart, granulocyte colony-stimulating factor (G-CSF) also exerts some indirect protective effects on accelerating repair and reducing adverse cardiovascular events by stimulating the bone marrow to mobilize the stern cell to the peripheral blood. In recent years a large number of clinical studies have been performed to detect the effect of G-CSF on cardiovascular diseases. The dosage of G-CSF, time of use, duration of treatment and combined therapy with other drugs may all influence the outcomes. In this article we summarize the clinic research results at home and abroad to provide more information for the further study of G-CSF and cardiovascular diseases.
出处
《心脏杂志》
CAS
2014年第1期83-86,共4页
Chinese Heart Journal