摘要
心血管疾病在现代社会中严重威胁人类健康,死亡率高。近年来,随着基因组学、蛋白质学和生物学的研究发展,确定心血管疾病的生物学标志物已经成为一种迫切需要,因为其能够客观反映生物学进程、发病机制和药理学改变,并可能成为可测定或评估的特征性指标。白介素-18(interleukin-18,IL-18)是近年来发现的具有多种生物学特性的炎性细胞因子,其作为细胞因子的重要成员在炎症过程中起重要作用。越来越多的实验和临床证据表明,IL-18在心血管疾病的发生、发展、预后及并发症中扮演着重要的角色。本文就IL-18与冠心病、高血压病、心力衰竭、房颤的关系作简要综述。
Cardiovascular diseases in modern society have a high mortality and pose serious threats to human health. With the development of genomics, there is an urgent need for identified biomarkers of cardiovascular diseases. Biomarkers of cardiovascular diseases can objectively reflect the biological process, pathogenesis and changes in pharmacology. Biomarkers of cardiovascular diseases may become important indicators. Interleukin-18 （IL-18） with many biological characteristics of inflammatory cyto- kines serves as an important member of the cytokines and plays a significant role in the inflammatory process. An increasing number of experiments and clinical evidence suggest that IL-18 is important in the occurrence, development, prognosis and complications of cardiovascular diseases. In this paper we will briefly review the relationship between IL-18 and coronary heart disease, hypertension, heart failure and atrial fibrillation.
出处
《心脏杂志》
CAS
2014年第1期101-103,共3页
Chinese Heart Journal
基金
国家自然科学基金项目(青年科学基金)资助(81200130)
