替勃龙对上皮性卵巢癌患者术后生存质量的影响

The effects of Tibolone on quality of life of the patients with epithelial ovarian cancer

目的探讨替勃龙对上皮性卵巢癌患者术后生存质量的影响。方法选取自2009年1月至2010年8月在盛京医院手术且病理诊断为上皮性卵巢癌的患者,在术后规范化疗过程中,进行Kupperman量表调查,将评分大于15分的患者根据是否愿意使用替勃龙药物治疗分为两组,实验组术后给予替勃龙2.5mg,每日1次口服,持续6个月。不愿意用药者为对照组。将30例完成6个月服药的卵巢癌患者按照临床期别及年龄与未服药的患者非随机配对进行分析。结果①Kupperman量表:患者服药6个月实验组评分为(4.97±1.88)分,明显低于对照组评分(20.53±5.16)分,差异有统计学意义(P<0.001);②EORTC-C30量表:功能子量表:实验组在身体功能、情绪功能、社会功能、角色功能等方面较对照评分高,与对照组比较差异有统计学意义(P<0.05);症状子量表:实验组在失眠、恶心、呕吐、疲劳、食欲等症状方面评分低,与对照组比较差异有统计学意义(P<0.05);总体健康情况评分:实验组显著高于对照组;③在化疗副反应方面:周围神经症状,实验组与对照组相比,实验组周围神经症状较轻,差异有统计学意义(P<0.05);白细胞计数:实验组较之对照组差异无统计学意义(P>0.05)。结论替勃龙可明显改善上皮性卵巢癌术后患者雌激素缺乏症状,减轻化疗副反应,提高患者的生存质量。

Objective To assess the effect of Tibolone on the quality of life of patients with epithelial ovarian cancer.Methods Patients with epithelial ovarian cancer who underwent surgery and regular adjuvant chemotherapy from January,2009 to August,2010 in Shengjing Hospital were recruited in this study.In the regular adjuvant chemotherapy,patients filled in Kupperman scale.The patients who got the score greater than 15 points would be divided into two groups based on whether they were willing to use Tibolone.The experimental group began to receive tibolone 2.5 mg once a day orally for 6 months 4 to 6 weeks postoperatively.Eventually there were 30 patients completing the experiment,then we chose non-randomly analysis to pair the control group according to the clinical stage and age.Results ① Kupperman Scale：The point of experimental group was（4.97±1.88）which was significantly lower than the control group（20.53±5.16）.② EORTC-C 30 questionnaire：Functional sub-scale：the experimental group scores in physical function,emotional function,social function and role function were significant higher than that in the control group;symptoms sub-scales：the scores of insomnia,nausea,vomiting,fatigue, loss of appetite and other symptoms in the experimental group were significant lower than that in the control group; as for the overall health score,the experimental group was significantly higher than control group.③ Side effects of chemotherapy：Patients in the experimental group were with mild symptoms of peripheral nerve compared to the control group（P＆lt;0.05）;The experimental group had no significant statistical difference with control group（P＆gt;0.05） in white blood cell count.Conclusion Tibolone can obviously reduce the symptoms of estrogen deficiency and the side effects of chemotherapy,also it can improve the quality of life for patients with epithelial ovarian cancer.