肝细胞性肝癌相关分子信号通路的研究进展

Signaling pathways in hepatocellular carcinoma

肝细胞性肝癌的发生是一个多阶段多因素的复杂过程,涉及到肝细胞生存、增殖、凋亡和分化等方面的相关机制.近来研究发现许多关键信号通路的异常活化与肝细胞性肝癌的关系密切,导致癌基因过表达,抑癌基因低表达,细胞周期紊乱,促进细胞凋亡.因此,本文就肝细胞性肝癌相关的重要信号转导通路作一综述.

Hepatocellular carcinoma is a complex multistep process involving progressive abnormalities of hepatocellular survival, proliferation, apoptosis and differentiation. Currently, accumulating evidence has demonstrated that the development of hepatocellular carcinoma is closely associated with dysregulation of several signaling pathways. Aberrant activation of these signaling cascades often leads to the over-expression of oncogenes and down-regulation of tumor suppressor genes, thus promoting cell cycle progression and apoptosis evasion. Here, we discuss some signaling pathways in hepatocellular carcinoma.