摘要
目的 探讨SD新生大鼠右心房注射前列腺素E2 （PGE2）产生呼吸暂停的作用机制.方法 将24只7～9天的SD大鼠随机分为3组,分别在右心房注射辣椒平、S-3144（P物质受体拮抗剂）和AH6809（前列腺素E2受体拮抗剂）前后注射PGE2,观察呼吸指标的变化.结果 右心房注射PGE2在7～9天大鼠引起呼吸暂停;AH6809可缩短PGE2产生的呼气时间约42％ （P＜0.05）,但辣椒平和S-3144对PGE2产生的呼吸暂停无明显影响.结论 新生大鼠右心房注射PGE2引起呼吸暂停,是通过作用于前列腺素E2（EP2）受体产生而与辣椒素受体和P物质受体无关.
Objective To explore the possible mechanism of right atrial injection of prostaglandin E2 （PGE2） on respiratory response in neonatal Sprague Dawley rats. Methods 24 SD rats at postnatal day 7-9（ P7- 9） received bo- lus injection of PGE2 before and after capsazepine, S-a144 （antagonist of NK1 receptor）, and AH6809 （antagonist of EP2 receptor） injection from the right atrium. The ventilatory alterations were observed and analyzed. Results Right at- rial bolus injection of PGEz generated apnea in PT 9 rats. AH6809 could evidently reduce the duration of expiration in- duced by PGE2 approximately 42~ （P〈0.05）, but capsazepine and S-3144 could not change. Conclusion Apnea induced by the right atrial injection of PGFe is partially induced by activating EP2 receptor but not capsaicin and neurokinin 1 receptors.
出处
《西部医学》
2014年第2期138-141,共4页
Medical Journal of West China
基金
国家自然科学基金(81170077)
