西地兰联合硫酸镁治疗房颤伴快速心室率患者的疗效观察

Effect of Cedilanid and Magnesium Sulphate in Treatment of Patients with Atrial Fibrillation and Rapid Ventricular Rate

目的观察西地兰联合硫酸镁治疗房颤伴快速心室率病人的临床疗效。方法选择房颤伴快速心室率病人50名,分为A、B两组,在常规治疗的基础上,A组25人单纯加用西地兰推注予以治疗,B组25人则给予西地兰+硫酸镁的联合治疗。观察记录治疗期间两组病人血压、心率、心电图变化、动态心室率变化、心律转复以及不良反应等,比较其临床疗效。结果 B组病人其心律转复成功率为64%、维持窦性心律者占36%,均明显高于A组的28%与12%(P<0.05),B组病人疗后心率即发生明显降低,且在疗后至疗后3天每天检查其心率都明显低于A组,差异均有统计学意义(P<0.05)。对比两组不良反应率,A组为8%,B组为12%,无统计学差异(P>0.05)。结论西地兰联合硫酸镁是治疗房颤伴快速心室率的一种行之有效的方法,能有效缓解病人病情,其心室率和心律复律的控制效果理想,且不良反应少,安全性高,值得在临床上推广。

Objective To observe the clinical effect of cedilanid and magnesium sulphate in the treatment of patients with atrial fibrillation and rapid ventricular rate. Methods 50 patients with atrial fibrillation and rapid ventricular rate were randomly divided into group A and group B. Based on the routine therapy, 25 patients in group A only received the injection of cedilanid; while 25 patients in group B received the combined treatment of cedilanid and magnesium sulphate. The blood pressure, heart rate, change in electrocardiography, and change in dynamic ventricular rate, cardioversion and adverse reactions during the treatment were observed, and the clinical effects were compared. Results The success rate of cardioversion in group B was 64% and the proportion of patients who maintained the sinus rhythm was 36%, which were all higher than those in group A （28% and 12% respectively） （P 〈0.05）. The heart rate of group B after treatment decreased significantly, and the heart rate every day within 3 days after treatment was all significantly lower than that in group A （P〈0.05）. The rate of adverse reactions in group A and group B was 8% and 12% respectively, without statistical difference （P 〉0.05）. Conclusions The combined treatment of cedilanid and magnesium sulphate is an effective way to treat patients with atrial fibrillation and rapid ventricular rate, which can effectively relieve patients＇ situation. Besides, the control effect of ventricular rate and car dioversion is ideal with few adverse reactions but high safety and thus it＇s worthy of clinical application.