前列地尔对于蛛网膜下腔出血患者脑血管痉挛的疗效分析

Analysis on the Effect of Alprostadil for the Treatment of Cerebral Vasospasm After Subarachnoid Hemorrhage

目的观察前列地尔注射液治疗蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的疗效和安全性。方法选择2008年1月至2012年12月在我院住院治疗的蛛网膜下腔出血的患者62例,随机分为观察组32例,对照组30例。在常规治疗的基础上,观察组给予前列地尔注射液治疗,对照组给予尼莫地平注射液治疗,比较两组患者治疗前后CVS缓解程度及不良反应。结果两组患者CVS的疗效无统计学差异,观察组的不良反应发生率较对照组低(P<0.05)。结论治疗SAH后CVS,前列地尔注射液与尼莫地平注射液疗效相当,但前列地尔注射液安全性更好,值得临床推广应用。

Objective To observe the curative effect and safety ofalprostadil injection for the treatment of cerebral vasospasm （CVS） after subarachnoid hemorrhage （SAH）. Methods 62 patients with CVS after SAH in our hospital from January 2008 to December 2012 were randomly divided into the observation group （n = 32） and control group （n = 30）. On the basis of conventional therapy, patients in the observation group received alprostadil injection, while patients in the control group received nirnodipine injection. The CVS relieving degree and adverse reaction were observed and compared. Results The curative effect of CVS had no statistical difference between the two groups （P 〉0.05）, but the incidence of adverse reaction in the observation group was significantly lower than that in the control group （P 〈0.05）. Conclusions For the treatment of CVS after SAH, alprostadil injection and nimodipine injection have similar curative effect, but alprostadil injection is safer than nimodipine injection, which is worthy of clinical application.