溶酶体组织蛋白酶B和D调控细胞凋亡及炎性反应的研究进展

Research Advance of Cathepsin B and D Regulating Apoptosis and Inflammation

组织蛋白酶是溶酶体水解蛋白酶家族的成员之一,它大量存在于活体细胞中,在细胞的蛋白水解中发挥重要作用。近年的研究表明,组织蛋白酶通过调控细胞凋亡及炎性反应可以干预肿瘤等多种疾病的发生及发展。本文针对近年来组织蛋白酶B和D在调控细胞凋亡及炎性反应等过程中发挥的作用作一系统性回顾及总结。

Cathepsin is a member of the lysosomal proteolytic enzyme family, which is abundant in living cells and plays an important role in proteolysis. Recent studies indicate that cathepsin can interfere the development of cancer and many other diseases through regulating apoptosis and inflammation. This paper made a systematic review about the role of cathepsin B and D in the regulation of apoptosis and inflammation.