皮肤晚期糖基化终末产物与2型糖尿病合并下肢动脉病变的相关性

Correlation research between skin advanced glycation end products and peripheral artery disease in type 2 diabetes mellitus

目的分析2型糖尿病伴下肢动脉病变患者皮肤晚期糖基化终末产物(AGEs)水平变化及其临床意义。方法 111例2型糖尿病患者,依据ABI(ankle-brachial index,踝肱指数)不同将其分为DM1组(0.9≤ABI≤1.3,n=46)、PAD1组(0.5≤ABI<0.9,n=51)、PAD2组(ABI<0.5,n=14),正常对照组35例,为同期体检健康人群。分别测定皮肤AGEs、糖化血红蛋白、ABI等指标。结果与正常对照组相比,糖尿病患者皮肤AGEs水平明显升高(P<0.05);与DM1组相比,PAD组皮肤AGEs水平明显增高(P<0.05),且PAD2组皮肤AGEs水平明显高于PAD1组。结论 2型糖尿病患者皮肤AGEs水平升高并可能参与了糖尿病下肢血管病变的发生,可以作为反映糖尿病下肢血管病变程度的指标之一。

Objective To analyze the level changes and clinical significance of skin advanced glycation end products （SAGEs） in type 2 diabetes with peripheral artery diseases. Methods According to the ankle - brachial index, 111 patients with type 2 diabetes were di- vided into three groups：DM1 group （0.9≤ABI≤1. 3 ,n =46） ,PAD1 group （0.5 ≤ABI 〈0.9,n =51 ） ,and PAD2 group （ ABI 〈0.5 ,n = 14） ;35 cases of normal control group were selected from the medical center for healthy people. SAGEs, glycated hemoglobin （HbA1 c）, ABI and other index were detected. Results Compared with normal control group, SAGEs level was obviously increased in patients with diabetes （P 〈 0.05 ） , compared with DM1 group, the level of SAGEs also increased in PAD group, and the level of SAGEs in PAD2 group was higher than that in PAD1 group. Conclusion The SAGEs level was obviously increased in patients with type 2 diabetes ,which may be involved in the pathogenesis of PAD, and could be used as an index for evaluating the severity of PAD.