乾坤丹3号治疗胰岛素抵抗临床观察

Clinical Observation of Qiankun 3 on Insulin Resistnce

目的：观察乾坤丹3号治疗胰岛素抵抗的临床疗效.方法：将符合标准的糖尿病胰岛素抵抗患者60例,随机分为两组.治疗组30例在口服促胰岛素分泌剂或皮下注射胰岛素的基础上加服乾坤丹;对照组30例在口服促胰岛素分泌剂或皮下注射胰岛素的基础上加服盐酸吡格列酮.两组治疗3个月.结果：治疗组中医症状总有效率为86.67％ （95％ CI=69.20％ ～ 96.20％）;对照组为66.67％ （95％ CI =47.20％ ～82.20％）;两组综合疗效比较（u=1.282 6,P=0.199 7）,差异尚未达到显著性意义;与对照组比较,治疗组可以明显改善2型糖尿病胰岛素抵抗患者的FPG、HbA1c、FINS及ISI等各项指标参数（P＜0.01）.结论：乾坤丹3号治疗2型糖尿病胰岛素抵抗的临床疗效优于盐酸吡格列酮的收益为OR=0.31 （95％CI=0.08～ 1.13）,NNT =5 （95％ CI =2.42 ～28.36）.

To observe the effect of Qiankun 3 on insulin resistnce. Methods： 60 cases of diabetic patients with insulin resistnce were randomly divided into two groups. 30 cases of treatment group were treated with Qiankun 3 decoction and insulin for 3 monthes. 30 cases of control group were treated oral Pioglitazone and insulin for 3 monthes. Results： After treatment, the total effective rate of the treatment group in TCM symptom was 86.67% （95% CI = 69.20% -96.20% ）, while that of the control group was 66.67% （95% CI = 47.20% ~ 82.20% ）. The total effective rate between the two groups had no significant difference （ u = 1. 282 6, P = O. 199 7 ）. Com- pared with the control group, the incidence of FPG,HbA1 c ,FINS and ISI of the treatment group could significantly improve （P 〈 0.01 ）. Conclusion： Clinical effective of Qiankun 3 decoction on diabetic patients with insulin resist- nce is better than Pioglitazone, OR = 0.31 （95 % CI = 0.08 - 1.13 ）, NNT = 5 （95 % CI = 2.42 - 28.36）.