新型多甲氧基取代二苯醚类化合物的合成

Synthesis of Novel Polymethoxy Diphenyl Ethers

以碘化亚铜为催化剂,Cs2CO3为碱,甲氧基取代苯酚（1）和甲氧基取代碘苯通过偶联反应形成C-O-C键,合成了27个新型的多甲氧基取代二苯醚类化合物,其结构经1H NMR和IR表征。最佳合成条件为：1 1.0mmol,CuI 0.10 mmol,Cs2CO32.0 mmol,DMF为溶剂,N2保护下于130℃下回流反应16 h。在最佳反应条件下,收率37%~94%。

Twenty seven novel polymethoxy diphenyl ethers were synthesized by coupling reaction of methoxy-iodobenzenes and methoxy-phenols（ 1） using CuI as the catalyst,cesium carbonate as the base. The structures were characterized by1H NMR and IR. The optimum reaction conditions at 130 ℃ for 16 h under N2 atmosphere were as follows： 1 was 1. 0 mmol,CuI was 0. 10 mmol,Cs2CO3 was 2. 0 mmol,DMF was the solvent. The yield were 37% ~ 94% under the optimum reaction conditions.